Antibiotics, Sedatives, and Catecholamines Further Compromise Sepsis-Induced Immune Suppression in Peripheral Blood Mononuclear Cells

• Published in: Critical care medicine Vol. 52; no. 4; p. 596
• Main Authors: Miller, Muska, Melis, Miranda J, Miller, James R C, Kleyman, Anna, Shankar-Hari, Manu, Singer, Mervyn
• Format: Journal Article
• Language: English
• Published: United States 01.04.2024
• Subjects: Anti-Bacterial Agents; Catecholamines; Ciprofloxacin; Cytokines; HLA-DR Antigens; Humans; Hypnotics and Sedatives - pharmacology; Immunosuppression Therapy; Leukocytes, Mononuclear; Norepinephrine; Propofol; Sepsis

We hypothesized that the immunosuppressive effects associated with antibiotics, sedatives, and catecholamines amplify sepsis-associated immune suppression through mitochondrial dysfunction, and there is a cumulative effect when used in combination. We thus sought to determine the impact of the exemp...