Reduced Immunocompetent B Cells and Increased Secondary Infection in Elderly Patients With Severe Sepsis

• Published in: Shock (Augusta, Ga.) Vol. 46; no. 3; p. 270
• Main Authors: Suzuki, Kodai, Inoue, Shigeaki, Kametani, Yoshie, Komori, Yukako, Chiba, Sayuri, Sato, Takehito, Inokuchi, Sadaki, Ogura, Shinji
• Format: Journal Article
• Language: English
• Published: United States 01.09.2016
• Subjects: Adult; Aged; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Critical Illness; Female; Fungi - immunology; Fungi - pathogenicity; Gram-Negative Bacteria - immunology; Gram-Negative Bacteria - pathogenicity; Humans; Immunity, Humoral - physiology; Immunocompetence - physiology; Immunoglobulin M - metabolism; Male; Middle Aged; Prospective Studies; Sepsis - immunology; Young Adult

Lymphocyte exhaustion was recently recognized as a mechanism of immunosuppression in sepsis. While B cells are known to play pivotal roles in bacterial infection and sepsis, changes in B-cell-mediated humoral immunity have not been evaluated in critically ill septic patients. We aimed to investigate...