Influence of P2Y12 polymorphisms on platelet activity but not ex-vivo antiplatelet effect of ticagrelor in healthy Chinese male subjects

• Published in: Blood coagulation & fibrinolysis Vol. 26; no. 8; p. 874
• Main Authors: Li, Mu-Peng, Tang, Jie, Wen, Zhi-Peng, Zhang, Yan-Jiao, Zhang, Wei, Zhou, Hong-Hao, Zhang, Zan-Ling, Chen, Xiao-Ping
• Format: Journal Article
• Language: English
• Published: England 01.12.2015
• Subjects: Adenosine - analogs & derivatives; Adenosine - pharmacology; Adenosine Diphosphate - pharmacology; Adolescent; Adult; Alleles; Asian Continental Ancestry Group; Blood Platelets - cytology; Blood Platelets - drug effects; Blood Platelets - metabolism; Drug Antagonism; Genotype; Healthy Volunteers; Heterotrimeric GTP-Binding Proteins - genetics; Humans; Male; Platelet Activation - drug effects; Platelet Activation - genetics; Platelet Aggregation - drug effects; Platelet Aggregation - genetics; Platelet-Rich Plasma - chemistry; Polymorphism, Single Nucleotide; Primary Cell Culture; Purinergic P2Y Receptor Antagonists - pharmacology; Receptors, Purinergic P2Y12 - genetics; Sequence Analysis, DNA
• ISSN: 1473-5733
• DOI: 10.1097/MBC.0000000000000308

Activation of platelet implicated a series of signal conduction including outside-in and inside-out related receptor-mediated signaling pathways. Ticagrelor is the first reversible P2Y12 receptor antagonist that exhibits rapid antiplatelet effect. Given that platelet aggregation varies among individ...