Post-LASIK Ectasia Versus Keratoconus: An In Vivo Confocal Microscopy Study
To examine and compare corneal cellular and subbasal nerve (SBN) characteristics in post-laser-assisted in situ keratomileusis ectasia (PLE) corneas, normal post-laser-assisted in situ keratomileusis corneas (PLC), keratoconus (KC) corneas, and normal virgin corneas (NC). In this cross-sectional com...
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Published in | Cornea Vol. 39; no. 8; p. 1006 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.08.2020
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Abstract | To examine and compare corneal cellular and subbasal nerve (SBN) characteristics in post-laser-assisted in situ keratomileusis ectasia (PLE) corneas, normal post-laser-assisted in situ keratomileusis corneas (PLC), keratoconus (KC) corneas, and normal virgin corneas (NC).
In this cross-sectional comparative study, 18 PLE eyes of 11 patients, 18 PLC of 15 cases, 32 KC eyes of 32 patients, and 29 NC of 29 subjects were assessed using in vivo confocal microscopy. The density of the basal epithelial cell (BEC), anterior keratocyte, posterior keratocyte, and endothelial cell layers, as well as the characteristics of SBN fibers, was compared between the 4 groups.
The density of the BEC and anterior and posterior keratocyte layers was significantly lower in KC compared with NC (-650 ± 190, P = 0.013; -181 ± 39, P < 0.001; and -36 ± 11, P = 0.021, respectively). However, there was no significant difference between PLE and PLC regarding these parameters (all Ps ≥ 0.6). Mean SBN parameters, including central corneal nerve branch density, nerve fiber length, total branch density, and nerve fiber area, were significantly lower in KC compared with NC and in PLE compared with PLC (all Ps ≤ 0.021).
The pathophysiology of PLE seems to differ from KC. Apparent changes in the BEC and anterior and posterior keratocytes associated with KC were not observed in PLE. However, SBNs seem to be involved in both conditions. |
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AbstractList | To examine and compare corneal cellular and subbasal nerve (SBN) characteristics in post-laser-assisted in situ keratomileusis ectasia (PLE) corneas, normal post-laser-assisted in situ keratomileusis corneas (PLC), keratoconus (KC) corneas, and normal virgin corneas (NC).
In this cross-sectional comparative study, 18 PLE eyes of 11 patients, 18 PLC of 15 cases, 32 KC eyes of 32 patients, and 29 NC of 29 subjects were assessed using in vivo confocal microscopy. The density of the basal epithelial cell (BEC), anterior keratocyte, posterior keratocyte, and endothelial cell layers, as well as the characteristics of SBN fibers, was compared between the 4 groups.
The density of the BEC and anterior and posterior keratocyte layers was significantly lower in KC compared with NC (-650 ± 190, P = 0.013; -181 ± 39, P < 0.001; and -36 ± 11, P = 0.021, respectively). However, there was no significant difference between PLE and PLC regarding these parameters (all Ps ≥ 0.6). Mean SBN parameters, including central corneal nerve branch density, nerve fiber length, total branch density, and nerve fiber area, were significantly lower in KC compared with NC and in PLE compared with PLC (all Ps ≤ 0.021).
The pathophysiology of PLE seems to differ from KC. Apparent changes in the BEC and anterior and posterior keratocytes associated with KC were not observed in PLE. However, SBNs seem to be involved in both conditions. |
Author | Jafarzadehpur, Ebrahim Hashemi, Hassan Seyedian, Mohammad Amin Amanzadeh, Kazem Khabazkhoob, Mehdi Mahbod, Mirgholamreza Fotouhi, Akbar Pakravan, Mohammad Alvani, Azam |
Author_xml | – sequence: 1 givenname: Azam surname: Alvani fullname: Alvani, Azam organization: Department of Ophthalmology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran – sequence: 2 givenname: Hassan surname: Hashemi fullname: Hashemi, Hassan organization: Department of Ophthalmology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran – sequence: 3 givenname: Mohammad surname: Pakravan fullname: Pakravan, Mohammad organization: Ophthalmic Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran – sequence: 4 givenname: Mirgholamreza surname: Mahbod fullname: Mahbod, Mirgholamreza organization: Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran – sequence: 5 givenname: Mohammad Amin surname: Seyedian fullname: Seyedian, Mohammad Amin organization: Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran – sequence: 6 givenname: Kazem surname: Amanzadeh fullname: Amanzadeh, Kazem organization: Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran – sequence: 7 givenname: Mehdi surname: Khabazkhoob fullname: Khabazkhoob, Mehdi organization: Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran – sequence: 8 givenname: Ebrahim surname: Jafarzadehpur fullname: Jafarzadehpur, Ebrahim organization: Department of Optometry, School of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran; and – sequence: 9 givenname: Akbar surname: Fotouhi fullname: Fotouhi, Akbar organization: Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran |
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Title | Post-LASIK Ectasia Versus Keratoconus: An In Vivo Confocal Microscopy Study |
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