The impact of variation in renal replacement therapy settings on piperacillin, meropenem, and vancomycin drug clearance in the critically ill: an analysis of published literature and dosing regimens

• Published in: Critical care medicine Vol. 42; no. 7; p. 1640
• Main Authors: Jamal, Janattul-Ain, Udy, Andrew A, Lipman, Jeffrey, Roberts, Jason A
• Format: Journal Article
• Language: English
• Published: United States 01.07.2014
• Subjects: Acute Kidney Injury - metabolism; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - pharmacology; Critical Illness; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Intensive Care Units; Male; Metabolic Clearance Rate; Middle Aged; Piperacillin - administration & dosage; Piperacillin - pharmacokinetics; Renal Replacement Therapy - methods; Thienamycins - administration & dosage; Thienamycins - pharmacokinetics; Vancomycin - administration & dosage; Vancomycin - pharmacokinetics

To describe the effect of different renal replacement therapy modalities and settings on the clearance of meropenem, piperacillin, and vancomycin in critically ill patients and to evaluate the frequency with which current dosing regimens achieve therapeutic concentrations. Regression analyses of pub...