Effects of the 5-HT1A receptor agonists buspirone and 8-OH-DPAT on pupil size in common marmosets

• Published in: Behavioural pharmacology Vol. 28; no. 4; p. 313
• Main Authors: Kotani, Manato, Urushino, Naoko, Natsutani, Itaru, Ogi, Yuji, Ikeda, Kazuhito
• Format: Journal Article
• Language: English
• Published: England 01.06.2017
• Subjects: 8-Hydroxy-2-(di-n-propylamino)tetralin - administration & dosage; 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology; Animals; Buspirone - administration & dosage; Buspirone - pharmacology; Callithrix; Dose-Response Relationship, Drug; Female; Infrared Rays; Male; Piperazines - pharmacology; Pupil - drug effects; Pyridines - pharmacology; Serotonin 5-HT1 Receptor Agonists - administration & dosage; Serotonin 5-HT1 Receptor Agonists - pharmacology

As pupil size is affected by psychotropic drugs in all mammals, it has been used as a well-established clinical indicator for the preclinical and clinical development of novel drugs. It has been reported that activation of the serotonin (5-HT)1A receptor differently affects pupil response in rodents...