RET Fusion Genes in Korean Non-Small Cell Lung Cancer

• Published in: Journal of Korean medical science Vol. 28; no. 10; pp. 1555 - 1558
• Main Authors: Yoo, Seung Soo, Jin, Guang, Jung, Hye Jin, Hong, Mi Jeong, Choi, Jin Eun, Jeon, Hyo-Sung, Lee, Shin Yup, Lim, Jeong Ok, Park, Jae Yong
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01.10.2013; 대한의학회
• Subjects: Asian Continental Ancestry Group - genetics; Brief Communication; Carcinoma, Non-Small-Cell Lung - epidemiology; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - surgery; Cytoskeletal Proteins - genetics; Female; Humans; Kinesin - genetics; Lung Neoplasms - epidemiology; Lung Neoplasms - genetics; Lung Neoplasms - surgery; Middle Aged; Oncogene Proteins, Fusion - genetics; Proto-Oncogene Proteins c-ret - genetics; Republic of Korea - epidemiology; Sequence Analysis, DNA; 의학일반; CCDC6; Korean; Carcinoma, Non-Small-Cell Lung; KIF5B; RET Fusion
• ISSN: 1011-8934; 1598-6357; 1598-6357
• DOI: 10.3346/jkms.2013.28.10.1555

Recently, rearranged during transfection (RET) fusions have been identified in approximately 1% of non-small cell lung cancer (NSCLC). To know the prevalence of RET fusion genes in Korean NSCLCs, we examined the RET fusion genes in 156 surgically resected NSCLCs using a reverse transcriptase polymerase chain reaction. Two KIF5B-RET fusions and one CCDC6-RET fusion were identified. All three patients were females and never smokers with adenocarcinomas. RET fusion genes were mutually exclusive from EGFR, KRAS mutations and EML4-ALK fusion. RET fusion genes occur 1.9% (3 of 156) of surgically treated NSCLC patients in Koreans.