Glaucoma diagnostic performance of GDxVCC and spectralis OCT on eyes with atypical retardation pattern

• Published in: Journal of glaucoma Vol. 22; no. 4; p. 317
• Main Authors: Hoesl, Laura Maria, Tornow, Ralf P, Schrems, Wolfgang A, Horn, Folkert K, Mardin, Christian Y, Kruse, Friedrich E, Juenemann, Anselm G M, Laemmer, Robert
• Format: Journal Article
• Language: English
• Published: United States 01.04.2013
• Subjects: Cross-Sectional Studies; Female; Glaucoma, Open-Angle - diagnosis; Humans; Intraocular Pressure; Male; Middle Aged; Nerve Fibers - pathology; Ocular Hypertension - diagnosis; Optic Disk - pathology; Optic Nerve Diseases - diagnosis; Reproducibility of Results; Retinal Ganglion Cells - pathology; ROC Curve; Scanning Laser Polarimetry - methods; Scanning Laser Polarimetry - standards; Sensitivity and Specificity; Tomography, Optical Coherence - methods; Tomography, Optical Coherence - standards; Visual Field Tests; Visual Fields
• DOI: 10.1097/IJG.0b013e318237c8c5

To investigate the impact of typical scan score (TSS) on discriminating glaucomatous and healthy eyes by scanning laser polarimetry and spectral domain optical coherence tomography (SD-OCT) in 32 peripapillary sectors. One hundred two glaucoma patients and 32 healthy controls underwent standard automated perimetry, 24-hour intraocular pressure profile, optic disc photography, GDxVCC, and SD-OCT measurements. For controls, only very typical scans (TSS=100) were accepted. Glaucoma patients were divided into 3 subgroups (very typical: TSS=100; typical: 99≥TSS≥80, atypical: TSS<80). Receiver operating characteristic curves were constructed for mean retinal nerve fiber layer values, sector data, and nerve fiber indicator (NFI). Sensitivity was estimated at ≥90% specificity to compare the discriminating ability of each imaging modality. For discrimination between healthy and glaucomatous eyes with very typical scans, the NFI and inferior sector analyses 26 to 27 demonstrated the highest sensitivity at ≥90% specificity in GDxVCC and SD-OCT, respectively. For the typical and atypical groups, sensitivity at ≥90% specificity decreased for all 32 peripapillary sectors on an average by 10.9% and 17.9% for GDxVCC and by 4.9% and 0.8% for SD-OCT. For GDxVCC, diagnostic performance of peripapillary sectors decreased with lower TSS, especially in temporosuperior and inferotemporal sectors (sensitivity at ≥90% specificity decreased by 55.3% and by 37.8% in the atypical group). Diagnostic accuracy is comparable for SD-OCT and GDxVCC if typical scans (TSS=100) are investigated. Decreasing TSS is associated with a decrease in diagnostic accuracy for discriminating healthy and glaucomatous eyes by scanning laser polarimetry. NFI is less influenced than the global or sector retinal nerve fiber layer thickness. The TSS score should be included in the standard printout. Diagnostic accuracy of SD-OCT is barely influenced by low TSS.