Protection of glycocalyx decreases platelet adhesion after ischaemia/reperfusion: an animal study

• Published in: European journal of anaesthesiology Vol. 31; no. 9; p. 474
• Main Authors: Chappell, Daniel, Brettner, Florian, Doerfler, Nina, Jacob, Matthias, Rehm, Markus, Bruegger, Dirk, Conzen, Peter, Jacob, Barbara, Becker, Bernhard F
• Format: Journal Article
• Language: English
• Published: England 01.09.2014
• Subjects: Adult; Animals; Antithrombin III - pharmacology; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Glycocalyx - drug effects; Glycocalyx - metabolism; Guinea Pigs; Humans; Hydrocortisone - pharmacology; Male; Myocardial Reperfusion Injury - drug therapy; Myocardial Reperfusion Injury - physiopathology; Platelet Adhesiveness - drug effects

Strategies targeting the protection of the vascular barrier, in particular the endothelial glycocalyx, are subjects of current research. Antithrombin III and hydrocortisone have been shown to reduce shedding of the glycocalyx following ischaemia/reperfusion. Platelet adhesion to endothelial cells is...