Dose-dependent Association between Intermediate-acting Neuromuscular-blocking Agents and Postoperative Respiratory Complications

• Published in: Anesthesiology (Philadelphia) Vol. 122; no. 6; pp. 1201 - 1213
• Main Authors: McLean, Duncan J., Diaz-Gil, Daniel, Farhan, Hassan N., Ladha, Karim S., Kurth, Tobias, Eikermann, Matthias
• Format: Journal Article
• Language: English
• Published: United States Copyright by , the American Society of Anesthesiologists, Inc. Wolters Kluwer Health, Inc 01.06.2015
• Subjects: Adrenergic alpha-Agonists - therapeutic use; Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors - adverse effects; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Neostigmine - adverse effects; Neuromuscular Blocking Agents - administration & dosage; Neuromuscular Blocking Agents - adverse effects; Norepinephrine - therapeutic use; Postoperative Complications - chemically induced; Postoperative Complications - epidemiology; Respiration Disorders - chemically induced; Respiration Disorders - epidemiology; Risk Factors; Treatment Outcome; Young Adult

BACKGROUND:Duration of action increases with repeated administration of neuromuscular-blocking agents, and intraoperative use of high doses of neuromuscular-blocking agent may affect respiratory safety. METHODS:In a hospital-based registry study on 48,499 patients who received intermediate-acting ne...