Perineural invasion in T1 oral squamous cell carcinoma indicates the need for aggressive elective neck dissection

• Published in: The American journal of surgical pathology Vol. 37; no. 8; p. 1164
• Main Authors: Tai, Shyh-Kuan, Li, Wing-Yin, Yang, Muh-Hwa, Chu, Pen-Yuan, Wang, Yi-Fen
• Format: Journal Article
• Language: English
• Published: United States 01.08.2013
• Subjects: Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - secondary; Carcinoma, Squamous Cell - surgery; Chi-Square Distribution; Disease-Free Survival; Elective Surgical Procedures; Humans; Kaplan-Meier Estimate; Logistic Models; Lymphatic Metastasis; Mouth Neoplasms - mortality; Mouth Neoplasms - pathology; Mouth Neoplasms - surgery; Multivariate Analysis; Neck Dissection - adverse effects; Neck Dissection - methods; Neck Dissection - mortality; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Peripheral Nerves - pathology; Peripheral Nerves - surgery; Predictive Value of Tests; Proportional Hazards Models; Retrospective Studies; Risk Factors; Staining and Labeling; Time Factors; Treatment Outcome

Observation or elective neck dissection (END) for cN0 neck remains controversial for the treatment of T1-2 oral squamous cell carcinoma (OSCC). Perineural invasion (PNI) has been recognized as a poor prognostic factor for OSCC. However, its significance in T1 OSCC remains unclear. A detailed histolo...