Decreased AQP4 Expression Aggravates ɑ-Synuclein Pathology in Parkinson’s Disease Mice, Possibly via Impaired Glymphatic Clearance

• Published in: Journal of molecular neuroscience Vol. 71; no. 12; pp. 2500 - 2513
• Main Authors: Cui, Huili, Wang, Wenkang, Zheng, Xinhui, Xia, Danhao, Liu, Han, Qin, Chi, Tian, Haiyan, Teng, Junfang
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2021; Springer Nature B.V
• Subjects: alpha-Synuclein - metabolism; Animals; Aquaporin 4; Aquaporin 4 - genetics; Aquaporin 4 - metabolism; Axons; Biomedical and Life Sciences; Biomedicine; Brain; Cell Biology; Dopamine; Fibrils; Glymphatic System - metabolism; Glymphatic System - pathology; Lewy bodies; Lewy Bodies - metabolism; Lewy Bodies - pathology; Macromolecules; Male; Mice; Mice, Inbred C57BL; Movement disorders; Neurochemistry; Neurodegenerative diseases; Neurology; Neurons; Neurosciences; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; Pathology; Proteomics; Substantia nigra; Substantia Nigra - metabolism; Substantia Nigra - pathology; Synuclein; Aquaporin 4; Α-synuclein; Glymphatic clearance; Neurodegeneration; Parkinson’s disease

The pathological hallmarks of Parkinson’s disease (PD), a neurodegenerative disorder, are the selective loss of dopamine neurons in the substantia nigra pars compacta (SNpc) and the presence of α-synuclein (α-syn) aggregates in the form of Lewy bodies/Lewy neurites (LBs/LNs) in neurons. Recent studi...