Lactoferrin in Pediatric Chronic Kidney Disease and Its Relationship with Cardiovascular Risk
Pediatric CKD is associated with a high risk of cardiovascular disease (CVD). Early detection of subclinical CVD in childhood CKD can be achieved through various cardiovascular (CV) assessments, including carotid intima-media thickness (cIMT), ambulatory blood pressure monitoring (ABPM), and arteria...
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Published in | Children (Basel) Vol. 11; no. 9; p. 1124 |
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Format | Journal Article |
Language | English |
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Abstract | Pediatric CKD is associated with a high risk of cardiovascular disease (CVD). Early detection of subclinical CVD in childhood CKD can be achieved through various cardiovascular (CV) assessments, including carotid intima-media thickness (cIMT), ambulatory blood pressure monitoring (ABPM), and arterial stiffness indices. Lactoferrin (LF), a key functional glycoprotein found in breast milk, has been linked to several diseases and has potential as a biomarker.
In our study of 102 children with CKD stages G1-G4, we explored the relationship between LF and CV risk markers.
We found that LF concentration was not related to the severity or underlying causes of childhood CKD, but was positively correlated with overweight/obesity. Lower LF levels were correlated with increased cIMT and elevated arterial stiffness indices. Notably, abnormalities in ABPM profiles were observed in up to 60% of the children with CKD, with low LF levels linked to nighttime hypertension, nocturnal non-dipping, and ABPM abnormalities.
In conclusion, LF shows promise as a biomarker for detecting subclinical CVD in children with CKD. Its potential utility in early detection could be instrumental in guiding timely interventions and improving long-term CV outcomes, although further research is needed to clarify the underlying mechanisms. |
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AbstractList | Pediatric CKD is associated with a high risk of cardiovascular disease (CVD). Early detection of subclinical CVD in childhood CKD can be achieved through various cardiovascular (CV) assessments, including carotid intima-media thickness (cIMT), ambulatory blood pressure monitoring (ABPM), and arterial stiffness indices. Lactoferrin (LF), a key functional glycoprotein found in breast milk, has been linked to several diseases and has potential as a biomarker.BACKGROUNDPediatric CKD is associated with a high risk of cardiovascular disease (CVD). Early detection of subclinical CVD in childhood CKD can be achieved through various cardiovascular (CV) assessments, including carotid intima-media thickness (cIMT), ambulatory blood pressure monitoring (ABPM), and arterial stiffness indices. Lactoferrin (LF), a key functional glycoprotein found in breast milk, has been linked to several diseases and has potential as a biomarker.In our study of 102 children with CKD stages G1-G4, we explored the relationship between LF and CV risk markers.METHODSIn our study of 102 children with CKD stages G1-G4, we explored the relationship between LF and CV risk markers.We found that LF concentration was not related to the severity or underlying causes of childhood CKD, but was positively correlated with overweight/obesity. Lower LF levels were correlated with increased cIMT and elevated arterial stiffness indices. Notably, abnormalities in ABPM profiles were observed in up to 60% of the children with CKD, with low LF levels linked to nighttime hypertension, nocturnal non-dipping, and ABPM abnormalities.RESULTSWe found that LF concentration was not related to the severity or underlying causes of childhood CKD, but was positively correlated with overweight/obesity. Lower LF levels were correlated with increased cIMT and elevated arterial stiffness indices. Notably, abnormalities in ABPM profiles were observed in up to 60% of the children with CKD, with low LF levels linked to nighttime hypertension, nocturnal non-dipping, and ABPM abnormalities.In conclusion, LF shows promise as a biomarker for detecting subclinical CVD in children with CKD. Its potential utility in early detection could be instrumental in guiding timely interventions and improving long-term CV outcomes, although further research is needed to clarify the underlying mechanisms.CONCLUSIONSIn conclusion, LF shows promise as a biomarker for detecting subclinical CVD in children with CKD. Its potential utility in early detection could be instrumental in guiding timely interventions and improving long-term CV outcomes, although further research is needed to clarify the underlying mechanisms. Background: Pediatric CKD is associated with a high risk of cardiovascular disease (CVD). Early detection of subclinical CVD in childhood CKD can be achieved through various cardiovascular (CV) assessments, including carotid intima–media thickness (cIMT), ambulatory blood pressure monitoring (ABPM), and arterial stiffness indices. Lactoferrin (LF), a key functional glycoprotein found in breast milk, has been linked to several diseases and has potential as a biomarker. Methods: In our study of 102 children with CKD stages G1–G4, we explored the relationship between LF and CV risk markers. Results: We found that LF concentration was not related to the severity or underlying causes of childhood CKD, but was positively correlated with overweight/obesity. Lower LF levels were correlated with increased cIMT and elevated arterial stiffness indices. Notably, abnormalities in ABPM profiles were observed in up to 60% of the children with CKD, with low LF levels linked to nighttime hypertension, nocturnal non-dipping, and ABPM abnormalities. Conclusions: In conclusion, LF shows promise as a biomarker for detecting subclinical CVD in children with CKD. Its potential utility in early detection could be instrumental in guiding timely interventions and improving long-term CV outcomes, although further research is needed to clarify the underlying mechanisms. Pediatric CKD is associated with a high risk of cardiovascular disease (CVD). Early detection of subclinical CVD in childhood CKD can be achieved through various cardiovascular (CV) assessments, including carotid intima-media thickness (cIMT), ambulatory blood pressure monitoring (ABPM), and arterial stiffness indices. Lactoferrin (LF), a key functional glycoprotein found in breast milk, has been linked to several diseases and has potential as a biomarker. In our study of 102 children with CKD stages G1-G4, we explored the relationship between LF and CV risk markers. We found that LF concentration was not related to the severity or underlying causes of childhood CKD, but was positively correlated with overweight/obesity. Lower LF levels were correlated with increased cIMT and elevated arterial stiffness indices. Notably, abnormalities in ABPM profiles were observed in up to 60% of the children with CKD, with low LF levels linked to nighttime hypertension, nocturnal non-dipping, and ABPM abnormalities. In conclusion, LF shows promise as a biomarker for detecting subclinical CVD in children with CKD. Its potential utility in early detection could be instrumental in guiding timely interventions and improving long-term CV outcomes, although further research is needed to clarify the underlying mechanisms. |
Audience | Academic |
Author | Hsu, Chien-Ning Tain, You-Lin Liao, Wei-Ting Ho, Chun-Yi Lu, Pei-Chen Chen, Wei-Ling |
AuthorAffiliation | 6 Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan 3 School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan; cnhsu@cgmh.org.tw 5 College of Medicine, Chang Gung University, Taoyuan 330, Taiwan 4 Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan 2 Department of Pediatrics, Kaohsiung Municipal Feng Shan Hospital—Under the Management of Chang Gung Medical Foundation, Kaohsiung 830, Taiwan 1 Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan; insomniac@cgmh.org.tw (C.-Y.H.); latina@cgmh.org.tw (P.-C.L.); weilingchen@cgmh.org.tw (W.-L.C.); winona0409@cgmh.org.tw (W.-T.L.) |
AuthorAffiliation_xml | – name: 1 Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan; insomniac@cgmh.org.tw (C.-Y.H.); latina@cgmh.org.tw (P.-C.L.); weilingchen@cgmh.org.tw (W.-L.C.); winona0409@cgmh.org.tw (W.-T.L.) – name: 2 Department of Pediatrics, Kaohsiung Municipal Feng Shan Hospital—Under the Management of Chang Gung Medical Foundation, Kaohsiung 830, Taiwan – name: 5 College of Medicine, Chang Gung University, Taoyuan 330, Taiwan – name: 6 Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan – name: 3 School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan; cnhsu@cgmh.org.tw – name: 4 Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan |
Author_xml | – sequence: 1 givenname: Chun-Yi surname: Ho fullname: Ho, Chun-Yi organization: Department of Pediatrics, Kaohsiung Municipal Feng Shan Hospital-Under the Management of Chang Gung Medical Foundation, Kaohsiung 830, Taiwan – sequence: 2 givenname: Pei-Chen orcidid: 0000-0003-2184-5478 surname: Lu fullname: Lu, Pei-Chen organization: Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan – sequence: 3 givenname: Wei-Ling surname: Chen fullname: Chen, Wei-Ling organization: Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan – sequence: 4 givenname: Wei-Ting surname: Liao fullname: Liao, Wei-Ting organization: Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan – sequence: 5 givenname: Chien-Ning orcidid: 0000-0001-7470-528X surname: Hsu fullname: Hsu, Chien-Ning organization: Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan – sequence: 6 givenname: You-Lin orcidid: 0000-0002-7059-6407 surname: Tain fullname: Tain, You-Lin organization: Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan |
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Nephrol. doi: 10.1007/s00467-019-04361-0 contributor: fullname: Halbach – ident: ref_42 doi: 10.3390/nu16162607 – volume: 3 start-page: 1 year: 2013 ident: ref_20 article-title: Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease publication-title: Kidney Int. Suppl. contributor: fullname: Levin |
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Snippet | Pediatric CKD is associated with a high risk of cardiovascular disease (CVD). Early detection of subclinical CVD in childhood CKD can be achieved through... Background: Pediatric CKD is associated with a high risk of cardiovascular disease (CVD). Early detection of subclinical CVD in childhood CKD can be achieved... |
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SubjectTerms | ambulatory blood pressure monitoring biomarker Biomarkers Blood pressure Body mass index cardiovascular disease Children Cholesterol chronic kidney disease Chronic kidney failure Congenital diseases Creatinine Diseases Hyperlipidemia Hypertension Kidney diseases lactoferrin Lactoferrins Measurement Obesity Overweight Pediatrics Plasma Risk factors Teenagers Triglycerides Ultrasonic imaging Uric acid |
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Title | Lactoferrin in Pediatric Chronic Kidney Disease and Its Relationship with Cardiovascular Risk |
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