Rheumatoid factor revisited

• Published in: Current opinion in rheumatology Vol. 16; no. 3; p. 246
• Main Authors: Dörner, Thomas, Egerer, Karl, Feist, Eugen, Burmester, Gerd R
• Format: Journal Article
• Language: English
• Published: United States 01.05.2004
• Subjects: Animals; Antibody Formation - immunology; Arthritis, Rheumatoid - immunology; B-Lymphocytes - immunology; Humans; Lymphocyte Activation - immunology; Mice; Rheumatoid Factor - immunology

Initial studies of the pathogenesis of rheumatoid arthritis focused on the role of rheumatoid factor and immune complex-associated vasculitis and synovitis. Subsequent work has delineated T cell responses, the role of cytokines, chemokines, and the aggressive nature of rheumatoid synovitis. Recent f...