Effect of Clopidogrel on Thrombus Formation in an Ex Vivo Parallel Plate Flow Chamber Model Cannot Be Reversed by Addition of Platelet Concentrates or vWF Concentrate

• Published in: Anesthesia and analgesia Vol. 124; no. 4; pp. 1091 - 1098
• Main Authors: Jahn, Kira, Suchodolski, Klaudiusz, Schäfer, Andreas, Sahlmann, Bianca, Küster, Uwe, Echtermeyer, Frank, Calmer, Simone, Theilmeier, Gregor, Johanning, Kai
• Format: Journal Article
• Language: English
• Published: United States International Anesthesia Research Society 01.04.2017
• Subjects: Anticoagulants - administration & dosage; Blood Coagulation - drug effects; Blood Coagulation - physiology; Blood Platelets - drug effects; Blood Platelets - physiology; Drug Therapy, Combination; Humans; Perfusion - instrumentation; Perfusion - methods; Platelet Aggregation Inhibitors - administration & dosage; Protein Array Analysis - instrumentation; Protein Array Analysis - methods; Thrombosis - pathology; Thrombosis - prevention & control; Ticlopidine - administration & dosage; Ticlopidine - analogs & derivatives; Treatment Outcome; von Willebrand Factor - administration & dosage

BACKGROUND:Hemorrhage is the most important complication of antithrombotic therapy with P2Y12 receptor blockers. The administration of platelet concentrates (PCs) and von Willebrand factor (vWF) concentrates are common procedures to normalize impaired primary hemostasis in bleeding patients. We test...