A Phase 1, Single-center, Double-blind, Placebo-controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Clinical Effects, and Pharmacokinetics–Pharmacodynamics of Intravenous Cyclopropyl-methoxycarbonylmetomidate (ABP-700) after a Single Ascending Bolus Dose - Struys, Michel M. R. F.; Valk, Beatrijs I.; Eleveld, Douglas J.; Absalom, Anthony R.; Meyer, Peter; Meier, Sascha; den Daas, Izaak; Chou, Thomas; van Amsterdam, Kai; Campagna, Jason A.; Sweeney, Steven P. (Anesthesiology (Philadelphia), 2017)
Keywords: Adolescent; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Etomidate - administration & dosage; Etomidate - analogs & derivatives; Etomidate - pharmacology; Female; Humans; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - pharmacology; Infusions, Intravenous; Male; Maximum Tolerated Dose; Middle Aged; Reference Values; Young Adult