Nephrotoxicity With Vancomycin in the Pediatric Population: A Systematic Review and Meta-Analysis

• Published in: The Pediatric infectious disease journal Vol. 37; no. 7; p. 654
• Main Authors: Fiorito, Theresa M, Luther, Megan K, Dennehy, Penelope H, LaPlante, Kerry L, Matson, Kelly L
• Format: Journal Article
• Language: English
• Published: United States 01.07.2018
• Subjects: Anti-Bacterial Agents - toxicity; Child; Humans; Intensive Care Units; Kidney - drug effects; Kidney - microbiology; Kidney - pathology; Kidney Diseases - chemically induced; Methicillin-Resistant Staphylococcus aureus - drug effects; Observational Studies as Topic; Odds Ratio; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Factors; Staphylococcal Infections - drug therapy; Vancomycin - toxicity

Vancomycin is frequently used to treat methicillin-resistant Staphylococcus aureus infections in pediatric patients. Vancomycin exposure may lead to an increase in frequency of nephrotoxicity. Our aim was to conduct a systematic review to describe predictors of nephrotoxicity associated with vancomy...