Effects of burn with and without Escherichia coli infection in rats on intestinal vs. splenic T-cell responses

• Published in: Critical care medicine Vol. 29; no. 12; p. 2245
• Main Authors: Ravindranath, T, Al-Ghoul, W, Namak, S, Fazal, N, Durazo-Arvizu, R, Choudhry, M, Sayeed, M M
• Format: Journal Article
• Language: English
• Published: United States 01.12.2001
• Subjects: Analysis of Variance; Animals; Burns - immunology; Burns - microbiology; Calcium Signaling; Concanavalin A; Escherichia coli Infections - etiology; Escherichia coli Infections - immunology; Immune Tolerance; Interleukin-2 - metabolism; Male; Peyer's Patches - immunology; Random Allocation; Rats; Rats, Sprague-Dawley; Sepsis - etiology; Sepsis - immunology; Spleen - immunology; Statistics, Nonparametric; T-Lymphocytes - metabolism

To evaluate the effect of burn injury with and without an Escherichia coliseptic complication on T-cell proliferation, interleukin-2 production, and Ca(2+) signaling responses in intestinal Peyer's patch and splenic T cells. Prospective, randomized, sham-controlled animal study. University medi...