Comparison of Rotational Thromboelastography Findings in Pseudoexfoliation Syndrome Patients and Healthy Controls
Rotational thromboelastography (ROTEM) is a useful test for studying the characteristics of fibrin clot formation. As patients with pseudoexfoliation (PEX) have an increased risk for thrombotic events, clot-forming dysfunction may play a role. The aim of this study is to compare ROTEM findings in PE...
Saved in:
Published in | Journal of glaucoma Vol. 25; no. 11; p. 879 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
01.11.2016
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | Rotational thromboelastography (ROTEM) is a useful test for studying the characteristics of fibrin clot formation. As patients with pseudoexfoliation (PEX) have an increased risk for thrombotic events, clot-forming dysfunction may play a role. The aim of this study is to compare ROTEM findings in PEX syndrome patients with age-matched and sex-matched healthy controls.
A total of 21 patients with PEX syndrome and 22 age-matched and sex-matched healthy controls were included. All study participants underwent detailed ophthalmologic and systemic medical examination, including blood pressure measurement, hemoglobin-hematocrit levels, platelet count, coagulation parameters including prothrombin time, activated partial thromboplastin time, fibrinogen levels, and D-dimer levels. Peripheral blood samples were collected and analyzed with ROTEM Coagulation Analyzer.
The mean age of patients with PEX and controls was 66.5±8.3 and 65.9±9.5 years, respectively (P=0.7). The 2 groups did not differ with respect to age, sex, hemoglobin, hematocrit, platelet numbers, prothrombin time, activated partial thromboplastin time, fibrinogen levels, D-dimer levels, and glucose levels. When extrinsic thromboelastometry results were analyzed, PEX patients showed a significantly decreased clotting time when compared with healthy controls (79.8 vs. 98.0 s; P=0.01), indicating faster clot formation. Other ROTEM parameters did now show any difference between the 2 groups.
PEX patients showed faster clotting time when compared with healthy controls. This fibrin clot formation dysfunction may lead to vascular thrombotic events in these patients. Further studies are needed to elucidate the exact underlying mechanism of thrombosis seen in PEX patients. |
---|---|
AbstractList | Rotational thromboelastography (ROTEM) is a useful test for studying the characteristics of fibrin clot formation. As patients with pseudoexfoliation (PEX) have an increased risk for thrombotic events, clot-forming dysfunction may play a role. The aim of this study is to compare ROTEM findings in PEX syndrome patients with age-matched and sex-matched healthy controls.
A total of 21 patients with PEX syndrome and 22 age-matched and sex-matched healthy controls were included. All study participants underwent detailed ophthalmologic and systemic medical examination, including blood pressure measurement, hemoglobin-hematocrit levels, platelet count, coagulation parameters including prothrombin time, activated partial thromboplastin time, fibrinogen levels, and D-dimer levels. Peripheral blood samples were collected and analyzed with ROTEM Coagulation Analyzer.
The mean age of patients with PEX and controls was 66.5±8.3 and 65.9±9.5 years, respectively (P=0.7). The 2 groups did not differ with respect to age, sex, hemoglobin, hematocrit, platelet numbers, prothrombin time, activated partial thromboplastin time, fibrinogen levels, D-dimer levels, and glucose levels. When extrinsic thromboelastometry results were analyzed, PEX patients showed a significantly decreased clotting time when compared with healthy controls (79.8 vs. 98.0 s; P=0.01), indicating faster clot formation. Other ROTEM parameters did now show any difference between the 2 groups.
PEX patients showed faster clotting time when compared with healthy controls. This fibrin clot formation dysfunction may lead to vascular thrombotic events in these patients. Further studies are needed to elucidate the exact underlying mechanism of thrombosis seen in PEX patients. |
Author | Akay, Olga M Goren Sahin, Deniz Sahin, Afsun |
Author_xml | – sequence: 1 givenname: Deniz surname: Goren Sahin fullname: Goren Sahin, Deniz organization: Departments of Hematology †Ophthalmology, Eskisehir Osmangazi University Medical School, Eskisehir, Turkey – sequence: 2 givenname: Afsun surname: Sahin fullname: Sahin, Afsun – sequence: 3 givenname: Olga M surname: Akay fullname: Akay, Olga M |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27275657$$D View this record in MEDLINE/PubMed |
BookMark | eNpNj9tKw0AQhhdR7EHfQGRfIHV3kt1NLyXYgxQsWsG7smkm7UqyE7Mp2Lc3eADn5mfg_4b5Ruzck0fGbqSYSDE1d8vH-UT8n0TLMzaUKtZRksq3ARuF8C4ECAB5yQZgwCitzJB9ZFQ3tnWBPKeSP1NnO0feVnxzaKnOCSsbOtq3tjmc-Mz5wvl94M7zdcBjQfhZUuW-Gf5y8kXPIF_3O_oucOsLvkBbdT2bke9aqsIVuyhtFfD6N8fsdfawyRbR6mm-zO5X0S5WWkaodZpjCWUKJjciTZL-eUSZxsYC2KQ3MGq6M2onY9BWSxkL0NL0_SIWCmDMbn_uNse8xmLbtK627Wn75w5fh11dXA |
CitedBy_id | crossref_primary_10_1097_IJG_0000000000000905 crossref_primary_10_1038_eye_2016_312 crossref_primary_10_1007_s10792_021_01950_7 crossref_primary_10_3390_ijms25031403 crossref_primary_10_1007_s10067_018_4134_y crossref_primary_10_1007_s00417_020_04668_x crossref_primary_10_1080_02713683_2018_1554152 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1097/IJG.0000000000000461 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1536-481X |
ExternalDocumentID | 27275657 |
Genre | Journal Article Comparative Study |
GroupedDBID | --- .-D .Z2 0R~ 2V- 53G 5GY 5VS 8L- AAAAV AAHPQ AAIQE AARTV AASCR AAYEP ABASU ABBUW ABDIG ABJNI ABOCM ABVCZ ABXRP ABXVJ ABZAD ACCJW ACDDN ACEWG ACGFO ACGFS ACILI ACWDW ACWRI ACXJB ACXNZ ADFPA ADGGA ADHPY ADNKB AE3 AE6 AEETU AENEX AFDTB AFUWQ AGINI AHQNM AHRYX AHVBC AINUH AJIOK AJNWD AJNYG AJZMW ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AWKKM BQLVK BS7 C45 CGR CS3 CUY CVF DIWNM DU5 DUNZO E.X EBS ECM EEVPB EIF EJD EX3 F2K F2L F5P FCALG FL- GNXGY GQDEL H0~ HLJTE HZ~ IKREB IN~ IPNFZ JK3 JK8 K8S KD2 KMI L-C N9A NPM N~M O9- OCUKA ODA OJAPA OL1 OLG OLV OLW OLZ OPUJH ORVUJ OUVQU OVD OVDNE OXXIT P-K P2P R58 RIG RLZ S4R S4S TEORI TSPGW V2I W3M WOQ WOW X3V X3W YFH ZB8 ZFV ZZMQN |
ID | FETCH-LOGICAL-c3561-e668bef2f827b70844202ee1837a22a4727759c75c1326a611302617f82d30522 |
IngestDate | Sat Sep 28 08:50:03 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 11 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c3561-e668bef2f827b70844202ee1837a22a4727759c75c1326a611302617f82d30522 |
PMID | 27275657 |
ParticipantIDs | pubmed_primary_27275657 |
PublicationCentury | 2000 |
PublicationDate | 2016-11-00 |
PublicationDateYYYYMMDD | 2016-11-01 |
PublicationDate_xml | – month: 11 year: 2016 text: 2016-11-00 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Journal of glaucoma |
PublicationTitleAlternate | J Glaucoma |
PublicationYear | 2016 |
SSID | ssj0020221 |
Score | 2.2255318 |
Snippet | Rotational thromboelastography (ROTEM) is a useful test for studying the characteristics of fibrin clot formation. As patients with pseudoexfoliation (PEX)... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 879 |
SubjectTerms | Aged Blood Coagulation - physiology Blood Coagulation Tests Exfoliation Syndrome - blood Female Fibrin Fibrinogen Degradation Products - metabolism Fibrinogen - metabolism Humans Intraocular Pressure Male Middle Aged Partial Thromboplastin Time Prothrombin Time Thrombelastography - methods |
Title | Comparison of Rotational Thromboelastography Findings in Pseudoexfoliation Syndrome Patients and Healthy Controls |
URI | https://www.ncbi.nlm.nih.gov/pubmed/27275657 |
Volume | 25 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1dT8IwFG1AE-OL8fvb9ME3MmVjW8sjIYKaiEYx8Y10W6uLuqlAYnjwt3v7NYigUXlYSEsW1nO4Pb30niJ0GIoEhCqPHdePA1igJMyhPGBOLYTpr0Z8wFwWJ190wtNb__wuuCuVPiarSwbRUTyaWVfyH1ShDXCVVbJ_QLa4KTTAe8AXroAwXH-FcXPyEMHKdT6wmb3uw1v-HOUcpPHAeFJXWqkqYFH7X6_6fJjk_F3kTxqayo1xLpCe_amqepMZdV2kJKOG2tDe_0bKggQfwvMVEb6dy_LwG_aQmpiWpaMilWNbG6I_LJjZeGQK7cune2YStCYV4YamJk_NJDZ8ho5P1SE4RXzVhc2WR-5EtKT6HJmpKK7dgc_O29pd0r58bds-AezLs0LWI9LEXhtd_9z7xVvbdpVRmVAZHzsy12OW66BuXFtsWSfHs76OtJI2t_iyLFHypLuMlgwYuKFJsoJKPFtFCxdm58Qaeh1zBecCj7mCZ3AFW67gNMNTXMGWK9hyBQNXsOEKtlxZR7etk27z1DHHbThxDVS0w8OQRlx4gnokIlXq-zAEnEPMJ8zzmA8PSoJ6TILYBc3PQlf-5w0CGD6fwKzheRtoLsszvoUwgfuAEgX1Lh3wKKGiyomQS9coqYo620aberB6L9pTpWeHcefbnl20OObcHpoX8CPm-6AIB9GBAu4TZVFg1w |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparison+of+Rotational+Thromboelastography+Findings+in+Pseudoexfoliation+Syndrome+Patients+and+Healthy+Controls&rft.jtitle=Journal+of+glaucoma&rft.au=Goren+Sahin%2C+Deniz&rft.au=Sahin%2C+Afsun&rft.au=Akay%2C+Olga+M&rft.date=2016-11-01&rft.eissn=1536-481X&rft.volume=25&rft.issue=11&rft.spage=879&rft_id=info:doi/10.1097%2FIJG.0000000000000461&rft_id=info%3Apmid%2F27275657&rft_id=info%3Apmid%2F27275657&rft.externalDocID=27275657 |