Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib - Gardner, Erin R; Burger, Herman; van Schaik, Ron H; van Oosterom, Allan T; de Bruijn, Ernst A; Guetens, Gunther; Prenen, Hans; de Jong, Floris A; Baker, Sharyn D; Bates, Susan E; Figg, William D; Verweij, Jaap; et al. (Clinical pharmacology and therapeutics, 2006)
Keywords: Adult; Aged; Aged, 80 and over; Alleles; ATP-Binding Cassette Transporters - genetics; Benzamides; Biological Transport, Active; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Line, Tumor; Cohort Studies; Cytochrome P-450 Enzyme System - genetics; Female; Gastrointestinal Neoplasms - genetics; Gastrointestinal Neoplasms - metabolism; Gene Frequency; Genotype; Humans; Imatinib Mesylate; Isoenzymes - genetics; Male; Middle Aged; Pharmaceutical Preparations - metabolism; Phenotype; Piperazines - pharmacokinetics; Protein-Tyrosine Kinases - antagonists & inhibitors; Proto-Oncogene Proteins c-kit - genetics; Pyrimidines - pharmacokinetics; Stromal Cells - metabolism