Endometrial Changes in Surgical Specimens of Perimenopausal Patients Treated With Ulipristal Acetate for Uterine Leiomyomas

• Published in: International journal of gynecological pathology Vol. 37; no. 6; p. 575
• Main Authors: Nogales, Francisco F, Crespo-Lora, Vicente, Cruz-Viruel, Nelly, Chamorro-Santos, Clara, Bergeron, Christine
• Format: Journal Article
• Language: English
• Published: United States 01.11.2018
• Subjects: Adult; Endometrium - drug effects; Endometrium - pathology; Endometrium - surgery; Female; Humans; Leiomyoma - drug therapy; Leiomyoma - pathology; Leiomyoma - surgery; Middle Aged; Norpregnadienes - pharmacology; Norpregnadienes - therapeutic use; Perimenopause; Uterine Neoplasms - drug therapy; Uterine Neoplasms - pathology; Uterine Neoplasms - surgery

Ulipristal acetate (UPA) is used to treat leiomyomas, and its effect on the endometrium has been studied in biopsy material. Reversible histologic modifications were found, named progesterone receptor modulators-associated endometrial changes (PAEC). However, hysterectomies from patients treated wit...