Therapeutic targeting of non-coding RNAs in cancer

• Published in: Biochemical journal Vol. 474; no. 24; p. 4219
• Main Authors: Slaby, Ondrej, Laga, Richard, Sedlacek, Ondrej
• Format: Journal Article
• Language: English
• Published: England 15.12.2017
• Subjects: microRNA; cancer; long non-coding RNA; delivery systems; non-coding RNA; therapy

The majority of the human genome encodes RNAs that do not code for proteins. These non-coding RNAs (ncRNAs) affect normal expression of the genes, including oncogenes and tumour suppressive genes, which make them a new class of targets for drug development in cancer. Although microRNAs (miRNAs) are...