The effect of pyridoxine deficiency on lysyl oxidase activity in the chick
The activity of lysyl oxidase, the enzyme responsible for the production of the precursor of the crosslinks of collagen and elastin, was measured in the aortas and epiphyseal cartilage of chicks raised on pyridoxine-deficient and control diets. Lysyl oxidase activity was diminished in both tissues i...
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| Published in | Experimental and molecular pathology Vol. 28; no. 3; pp. 301 - 308 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Inc
01.06.1978
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| Abstract | The activity of lysyl oxidase, the enzyme responsible for the production of the precursor of the crosslinks of collagen and elastin, was measured in the aortas and epiphyseal cartilage of chicks raised on pyridoxine-deficient and control diets. Lysyl oxidase activity was diminished in both tissues in the deficient chicks, although the activity declined more slowly in the aorta. Deficient chicks given a large dose of pyridoxine 14 hr before sacrifice showed a marked increase in lysyl oxidase levels in both tissues. It is concluded that a pyridoxine derivative as well as copper are essential cofactors for lysyl oxidase. |
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| AbstractList | The activity of lysyl oxidase, the enzyme responsible for the production of the precursor of the crosslinks of collagen and elastin, was measured in the aortas and epiphyseal cartilage of chicks raised on pyridoxine-deficient and control diets. Lysyl oxidase activity was diminished in both tissues in the deficient chicks, although the activity declined more slowly in the aorta. Deficient chicks given a large dose of pyridoxine 14 hr before sacrifice showed a marked increase in lysyl oxidase levels in both tissues. It is concluded that a pyridoxine derivative as well as copper are essential cofactors for lysyl oxidase. |
| Author | Fraser, D.R. Levene, C.I. Murray, J.C. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25785$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/0003-9861(74)90123-4 10.1093/ajcn/4.4.318 10.1016/0003-9861(72)90302-5 10.1093/jn/102.10.1259 10.1016/S0006-291X(67)80045-7 10.1002/path.1700720110 10.1152/physrev.1975.55.3.418 10.1007/BF01901473 10.1111/j.1432-1033.1976.tb10175.x 10.1021/bi00856a025 10.1172/JCI103055 10.1016/0005-2744(74)90226-5 10.1016/0304-4165(70)90154-6 10.1042/bj0960004C 10.1016/0009-8981(67)90209-4 10.1016/0003-2697(66)90219-3 10.1021/bi00868a007 10.1016/0005-2795(74)90267-0 10.1038/251105a0 10.1016/S0140-6736(77)92061-X |
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Biochem. doi: 10.1016/0003-2697(66)90219-3 contributor: fullname: Hutton – volume: 5 start-page: 1154 year: 1966 ident: 10.1016/0014-4800(78)90004-7_BIB17 article-title: Conversion of proline to collagen hydroxyproline publication-title: Biochemistry doi: 10.1021/bi00868a007 contributor: fullname: Manning – volume: 61 start-page: 708 year: 1968 ident: 10.1016/0014-4800(78)90004-7_BIB21 article-title: The cross-linking of collagen and elastin: Enzymatic conversion of lysine in peptide linkage to alpha-aminoadipic-delta-semialdehyde (allysine) by an extract from bone contributor: fullname: Pinnell – volume: 365 start-page: 223 year: 1974 ident: 10.1016/0014-4800(78)90004-7_BIB10 article-title: A microenvironmental probe of elastin. Properties of a solubilized Congo red-elastin complex publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2795(74)90267-0 contributor: fullname: Kagan – volume: 251 start-page: 105 year: 1974 ident: 10.1016/0014-4800(78)90004-7_BIB1 article-title: Biological significance of the intermolecular crosslinks of collagen publication-title: Nature (London) doi: 10.1038/251105a0 contributor: fullname: Bailey – volume: 1 start-page: 628 year: 1977 ident: 10.1016/0014-4800(78)90004-7_BIB16 article-title: The aetiological role of maternal vitamin-B6 deficiency in the development of atherosclerosis publication-title: Lancet doi: 10.1016/S0140-6736(77)92061-X contributor: fullname: Levene |
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| Snippet | The activity of lysyl oxidase, the enzyme responsible for the production of the precursor of the crosslinks of collagen and elastin, was measured in the aortas... |
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| SubjectTerms | Amino Acid Oxidoreductases - metabolism Animals Aorta - enzymology Cartilage - enzymology Chickens Collagen - metabolism Copper - deficiency Elastin - metabolism Male Protein-Lysine 6-Oxidase - metabolism Vitamin B 6 Deficiency - enzymology Vitamin B 6 Deficiency - pathology |
| Title | The effect of pyridoxine deficiency on lysyl oxidase activity in the chick |
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