The effect of pyridoxine deficiency on lysyl oxidase activity in the chick

The activity of lysyl oxidase, the enzyme responsible for the production of the precursor of the crosslinks of collagen and elastin, was measured in the aortas and epiphyseal cartilage of chicks raised on pyridoxine-deficient and control diets. Lysyl oxidase activity was diminished in both tissues i...

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Published inExperimental and molecular pathology Vol. 28; no. 3; pp. 301 - 308
Main Authors Murray, J.C., Fraser, D.R., Levene, C.I.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.06.1978
Subjects
Amino Acid Oxidoreductases - metabolism
Animals
Aorta - enzymology
Cartilage - enzymology
Chickens
Collagen - metabolism
Copper - deficiency
Elastin - metabolism
Male
Protein-Lysine 6-Oxidase - metabolism
Vitamin B 6 Deficiency - enzymology
Vitamin B 6 Deficiency - pathology
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Summary:The activity of lysyl oxidase, the enzyme responsible for the production of the precursor of the crosslinks of collagen and elastin, was measured in the aortas and epiphyseal cartilage of chicks raised on pyridoxine-deficient and control diets. Lysyl oxidase activity was diminished in both tissues in the deficient chicks, although the activity declined more slowly in the aorta. Deficient chicks given a large dose of pyridoxine 14 hr before sacrifice showed a marked increase in lysyl oxidase levels in both tissues. It is concluded that a pyridoxine derivative as well as copper are essential cofactors for lysyl oxidase.
Bibliography:ObjectType-Article-1
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ISSN:0014-4800
1096-0945
DOI:10.1016/0014-4800(78)90004-7