Use of antidepressants in patients with depression and comorbid diabetes mellitus: a systematic review

• Published in: Acta neuropsychiatrica Vol. 29; no. 3; pp. 127 - 139
• Main Authors: Roopan, Subethini, Larsen, Erik Roj
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.06.2017
• Subjects: Acetamides - adverse effects; Acetamides - therapeutic use; Adult; Aged; Antidepressants; Antidepressive Agents - adverse effects; Antidepressive Agents - therapeutic use; Antidepressive Agents, Second-Generation - administration & dosage; Antidepressive Agents, Second-Generation - therapeutic use; Antidepressive Agents, Tricyclic - adverse effects; Antidepressive Agents, Tricyclic - therapeutic use; Bupropion - adverse effects; Bupropion - therapeutic use; Clinical trials; Comorbidity; Depression - complications; Depression - drug therapy; Diabetes; Diabetes Mellitus - drug therapy; Diabetes Mellitus - psychology; Double-Blind Method; Drug therapy; Female; Glucose; Humans; Hyperglycemia - chemically induced; Hyperglycemia - complications; Hypnotics and Sedatives - adverse effects; Hypnotics and Sedatives - therapeutic use; Hypoglycemia - chemically induced; Hypoglycemia - complications; Insulin resistance; Male; Mental depression; Middle Aged; Plasma; Psychotherapy; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors - adverse effects; Selective Serotonin Reuptake Inhibitors - therapeutic use; Systematic review; Young Adult; diabetes mellitus; mood disorder; depression; antidepressant

Depression may be difficult to treat and with comorbid diabetes mellitus (DM) it is an even bigger challenge. This article aims to evaluate antidepressants most suitable for patients with depression and comorbid DM. Design and methods Initially we searched for randomised, controlled double-blind tri...