Erdosteine treatment attenuates oxidative stress and fibrosis in experimental biliary obstruction

• Published in: Pediatric surgery international Vol. 23; no. 3; pp. 233 - 241
• Main Authors: Sener, Göksel, Sehirli, A Ozer, Toklu, Hale Z, Yuksel, Meral, Ercan, Feriha, Gedik, Nursal
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01.03.2007
• Subjects: Alanine Transaminase - blood; Animals; Aspartate Aminotransferases - blood; Cytokines - blood; Expectorants - therapeutic use; Glutathione - blood; L-Lactate Dehydrogenase - blood; Liver - metabolism; Liver - pathology; Liver Cirrhosis, Biliary - drug therapy; Liver Cirrhosis, Biliary - etiology; Liver Cirrhosis, Biliary - metabolism; Liver Cirrhosis, Biliary - pathology; Liver Cirrhosis, Experimental - drug therapy; Liver Cirrhosis, Experimental - etiology; Liver Cirrhosis, Experimental - metabolism; Liver Cirrhosis, Experimental - pathology; Male; Malondialdehyde - blood; Microbial Collagenase - metabolism; Oxidative Stress - drug effects; Peroxidase - metabolism; Rats; Thioglycolates - therapeutic use; Thiophenes - therapeutic use

Oxidative stress, in particular lipid peroxidation, induces collagen synthesis and causes fibrosis. The aim of this study was to assess the antioxidant and antifibrotic effects of erdosteine on liver fibrosis induced by biliary obstruction in rats. Liver fibrosis was induced in Wistar albino rats by...