The Unfinished Puzzle of Glutathione Physiological Functions, an Old Molecule That Still Retains Many Enigmas

• Published in: Antioxidants & redox signaling Vol. 27; no. 15; p. 1127
• Main Authors: Toledano, Michel B, Huang, Meng-Er
• Format: Journal Article
• Language: English
• Published: United States 20.11.2017
• Subjects: Animals; Antioxidants - metabolism; Endoplasmic Reticulum - metabolism; Eukaryotic Cells - metabolism; Glutathione - metabolism; Humans; Mitochondria - metabolism; Oxidation-Reduction; Proteolysis; cancer; glutathione degradation; drug resistance; iron homeostasis; glutathione compartmentalization; glutathione

Glutathione (GSH) is the most abundant nonprotein thiol found in living organisms. Since its discovery 130 years ago, understanding its cellular functions has been the subject of intensive research. Common scientific knowledge states that GSH is a major nonenzymatic antioxidant and redox buffer. Rec...