Aortic smooth muscle TRPV4 channels regulate vasoconstriction in high salt-induced hypertension

• Published in: Hypertension research Vol. 46; no. 10; pp. 2356 - 2367
• Main Authors: Wen, Xin, Peng, Yidi, Peng, Yuefeng, Zhu, Yuzhong, Yu, Fan, Geng, Li, Zhou, Tingting, Wang, Xianfeng, Feng, Lei, Meng, Qingyou
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.10.2023
• Subjects: Coronary vessels; Hypertension; Pathogenesis; Salt; Smooth muscle; Hypertension; Transient receptor potential vanilloid 4 (TRPV4); Aorta; Smooth muscle; Contraction

Recent studies have focused on the contribution of vascular endothelial transient receptor potential vanilloid 4 (TRPV4) channels to hypertension. However, in hypertension, TRPV4 channels in vascular smooth muscle remain unexplored. In the present study, we performed wire myograph experiments in iso...