Near-infrared light-responsive hybrid hydrogels for the synergistic chemo-photothermal therapy of oral cancer
Light-stimulus-responsive therapies have been recognized as a promising strategy for the efficient and safe treatment of oral squamous cell carcinoma (OSCC). Hydrogels have emerged as a promising multifunctional platform combining localized drug delivery and sustained drug release with multimodal pr...
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Published in | Nanoscale Vol. 13; no. 4; pp. 17168 - 17182 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Cambridge
Royal Society of Chemistry
21.10.2021
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Abstract | Light-stimulus-responsive therapies have been recognized as a promising strategy for the efficient and safe treatment of oral squamous cell carcinoma (OSCC). Hydrogels have emerged as a promising multifunctional platform combining localized drug delivery and sustained drug release with multimodal properties for combined OSCC therapy. However, inaccurate drug release and limited light-absorption efficiency have hindered their on-demand chemo-photothermal applications. To tackle these problems, an injectable and near-infrared (NIR) light-responsive hybrid system was developed by incorporating light-responsive mesoporous silica nanoparticles (MSNs) as doxorubicin (DOX) carriers into the IR820/methylcellulose hydrogel networks for chemophotothermal therapy. Under NIR radiation, the incorporated IR820, a new green cyanine dye, was excited to induce photothermal effects against tumor cells. Meanwhile, MSNs achieved self-degradation-controlled DOX release
via
the cleavage of diselenide bonds induced by reactive oxygen species. Through the combination of chemotherapy and phototherapy, a long-lasting synergistic anti-tumor effect was achieved
in vitro
and
in vivo
with less toxicity. These findings demonstrate the potential of light-responsive hydrogels as a multifunctional platform for accurate synergistic chemophotothermal treatment of OSCC.
A near-infrared light-responsive hybrid hydrogel was injected in the tumor site. IR820 could not only produce local heat for photothermal therapy, but also generate singlet oxygen to induce the degradation of MSNs for controllable drug release. |
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AbstractList | Light-stimulus-responsive therapies have been recognized as a promising strategy for the efficient and safe treatment of oral squamous cell carcinoma (OSCC). Hydrogels have emerged as a promising multifunctional platform combining localized drug delivery and sustained drug release with multimodal properties for combined OSCC therapy. However, inaccurate drug release and limited light-absorption efficiency have hindered their on-demand chemo-photothermal applications. To tackle these problems, an injectable and near-infrared (NIR) light-responsive hybrid system was developed by incorporating light-responsive mesoporous silica nanoparticles (MSNs) as doxorubicin (DOX) carriers into the IR820/methylcellulose hydrogel networks for chemophotothermal therapy. Under NIR radiation, the incorporated IR820, a new green cyanine dye, was excited to induce photothermal effects against tumor cells. Meanwhile, MSNs achieved self-degradation-controlled DOX release
via
the cleavage of diselenide bonds induced by reactive oxygen species. Through the combination of chemotherapy and phototherapy, a long-lasting synergistic anti-tumor effect was achieved
in vitro
and
in vivo
with less toxicity. These findings demonstrate the potential of light-responsive hydrogels as a multifunctional platform for accurate synergistic chemophotothermal treatment of OSCC. Light-stimulus-responsive therapies have been recognized as a promising strategy for the efficient and safe treatment of oral squamous cell carcinoma (OSCC). Hydrogels have emerged as a promising multifunctional platform combining localized drug delivery and sustained drug release with multimodal properties for combined OSCC therapy. However, inaccurate drug release and limited light-absorption efficiency have hindered their on-demand chemo-photothermal applications. To tackle these problems, an injectable and near-infrared (NIR) light-responsive hybrid system was developed by incorporating light-responsive mesoporous silica nanoparticles (MSNs) as doxorubicin (DOX) carriers into the IR820/methylcellulose hydrogel networks for chemophotothermal therapy. Under NIR radiation, the incorporated IR820, a new green cyanine dye, was excited to induce photothermal effects against tumor cells. Meanwhile, MSNs achieved self-degradation-controlled DOX release via the cleavage of diselenide bonds induced by reactive oxygen species. Through the combination of chemotherapy and phototherapy, a long-lasting synergistic anti-tumor effect was achieved in vitro and in vivo with less toxicity. These findings demonstrate the potential of light-responsive hydrogels as a multifunctional platform for accurate synergistic chemophotothermal treatment of OSCC. Light-stimulus-responsive therapies have been recognized as a promising strategy for the efficient and safe treatment of oral squamous cell carcinoma (OSCC). Hydrogels have emerged as a promising multifunctional platform combining localized drug delivery and sustained drug release with multimodal properties for combined OSCC therapy. However, inaccurate drug release and limited light-absorption efficiency have hindered their on-demand chemo-photothermal applications. To tackle these problems, an injectable and near-infrared (NIR) light-responsive hybrid system was developed by incorporating light-responsive mesoporous silica nanoparticles (MSNs) as doxorubicin (DOX) carriers into the IR820/methylcellulose hydrogel networks for chemophotothermal therapy. Under NIR radiation, the incorporated IR820, a new green cyanine dye, was excited to induce photothermal effects against tumor cells. Meanwhile, MSNs achieved self-degradation-controlled DOX release via the cleavage of diselenide bonds induced by reactive oxygen species. Through the combination of chemotherapy and phototherapy, a long-lasting synergistic anti-tumor effect was achieved in vitro and in vivo with less toxicity. These findings demonstrate the potential of light-responsive hydrogels as a multifunctional platform for accurate synergistic chemophotothermal treatment of OSCC. A near-infrared light-responsive hybrid hydrogel was injected in the tumor site. IR820 could not only produce local heat for photothermal therapy, but also generate singlet oxygen to induce the degradation of MSNs for controllable drug release. |
Author | Tan, Bowen Chen, Fangman Li, Longjiang Huang, Nengwen Shao, Dan Liu, Yunkun Yang, Chao Liao, Jinfeng Li, Jinjin Wu, Chenzhou Wu, Yongzhi |
AuthorAffiliation | State Key Laboratory of Oral Diseases National Clinical Research Centre for Oral Diseases Institutes for Life Sciences South China University of Technology Sichuan University School of Medicine West China Hospital of Stomatology School of Biomedical Sciences and Engineering |
AuthorAffiliation_xml | – name: School of Biomedical Sciences and Engineering – name: South China University of Technology – name: Institutes for Life Sciences – name: School of Medicine – name: West China Hospital of Stomatology – name: National Clinical Research Centre for Oral Diseases – name: Sichuan University – name: State Key Laboratory of Oral Diseases |
Author_xml | – sequence: 1 givenname: Yongzhi surname: Wu fullname: Wu, Yongzhi – sequence: 2 givenname: Fangman surname: Chen fullname: Chen, Fangman – sequence: 3 givenname: Nengwen surname: Huang fullname: Huang, Nengwen – sequence: 4 givenname: Jinjin surname: Li fullname: Li, Jinjin – sequence: 5 givenname: Chenzhou surname: Wu fullname: Wu, Chenzhou – sequence: 6 givenname: Bowen surname: Tan fullname: Tan, Bowen – sequence: 7 givenname: Yunkun surname: Liu fullname: Liu, Yunkun – sequence: 8 givenname: Longjiang surname: Li fullname: Li, Longjiang – sequence: 9 givenname: Chao surname: Yang fullname: Yang, Chao – sequence: 10 givenname: Dan surname: Shao fullname: Shao, Dan – sequence: 11 givenname: Jinfeng surname: Liao fullname: Liao, Jinfeng |
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SubjectTerms | Anticancer properties Biocompatibility Cancer Cyanine dyes Doxorubicin Electromagnetic absorption Hybrid systems Hydrogels Light Nanoparticles Near infrared radiation Silicon dioxide Toxicity |
Title | Near-infrared light-responsive hybrid hydrogels for the synergistic chemo-photothermal therapy of oral cancer |
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