Paradoxical Sleep Rebound Without Previous Debt: The Effect of Minute Doses of Clonidine in Man

• Published in: Sleep (New York, N.Y.) Vol. 6; no. 1; pp. 60 - 66
• Main Authors: Gaillard, J.-M., Iorio, G., Kafi, S., Blois, R.
• Format: Journal Article
• Language: English
• Published: United States 01.01.1983
• Subjects: Adolescent; Adult; Animals; Brain - drug effects; Cats; Clonidine - metabolism; Clonidine - pharmacology; Female; Half-Life; Humans; Kinetics; Male; Rats; Receptors, Adrenergic, alpha - drug effects; Sleep Deprivation; Sleep, REM - drug effects

This report describes an experimental condition in which clonidine administration does not modify paradoxical sleep (PS) directly, but is followed by a secondary rebound. After oral consumption of minute doses of clonidine (CLN), 12 subjects showed no direct effect of CLN, but showed a significant i...