Paradoxical Sleep Rebound Without Previous Debt: The Effect of Minute Doses of Clonidine in Man

This report describes an experimental condition in which clonidine administration does not modify paradoxical sleep (PS) directly, but is followed by a secondary rebound. After oral consumption of minute doses of clonidine (CLN), 12 subjects showed no direct effect of CLN, but showed a significant i...

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Bibliographic Details
Published inSleep (New York, N.Y.) Vol. 6; no. 1; pp. 60 - 66
Main Authors Gaillard, J.-M., Iorio, G., Kafi, S., Blois, R.
Format Journal Article
LanguageEnglish
Published United States 01.01.1983
Subjects
Adolescent
Adult
Animals
Brain - drug effects
Cats
Clonidine - metabolism
Clonidine - pharmacology
Female
Half-Life
Humans
Kinetics
Male
Rats
Receptors, Adrenergic, alpha - drug effects
Sleep Deprivation
Sleep, REM - drug effects
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Summary:This report describes an experimental condition in which clonidine administration does not modify paradoxical sleep (PS) directly, but is followed by a secondary rebound. After oral consumption of minute doses of clonidine (CLN), 12 subjects showed no direct effect of CLN, but showed a significant increase of PS production in the following placebo night. Four other subjects experienced a decrease of PS under CLN and no rebound the next night. In addition, these four subjects had mechanisms of slow wave sleep production significantly weaker than the first 12 subjects.
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ISSN:0161-8105
1550-9109
DOI:10.1093/sleep/6.1.60