The effect of resonance on transient microbubble acoustic response: Experimental observations and numerical simulations
A large number of acoustic signals from single lipid-shelled Definity (Lantheus Medical Imaging, N. Billerica, MA) microbubbles have been measured using a calibrated microacoustic system, and a unique transient characteristic of resonance has been identified in the onset of scatter. Comparison of th...
Saved in:
Published in | The Journal of the Acoustical Society of America Vol. 143; no. 3; p. 1392 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.03.2018
|
Online Access | Get more information |
Cover
Loading…
Abstract | A large number of acoustic signals from single lipid-shelled Definity
(Lantheus Medical Imaging, N. Billerica, MA) microbubbles have been measured using a calibrated microacoustic system, and a unique transient characteristic of resonance has been identified in the onset of scatter. Comparison of the numerically obtained response of microbubbles with acoustic measurements provides good agreement for a soft shell that is characterized by small area dilatation modulus and strain softening behavior, and identifies time to maximum radial excursion and scatter as a robust marker of resonance during transient response. As the sound amplitude increases a two-population pattern emerges in the time delay vs the fundamental acoustic scatter plots, consisting of an initial part pertaining to microbubbles with less than resonant rest radii, which corresponds to the weaker second harmonic resonance, and the dominant resonant envelope pertaining to microbubbles with resonant and greater than resonant rest radii, which corresponds to the primary and subharmonic resonances. Consequently, a wider resonant spectrum is observed. It is a result of the strain softening nature of soft lipid shells, based on which the microbubble sizes corresponding to the above resonances decrease as the sound amplitude increases. This bares an impact on the selection of an optimal microbubble size pertaining to subharmonic imaging. |
---|---|
AbstractList | A large number of acoustic signals from single lipid-shelled Definity
(Lantheus Medical Imaging, N. Billerica, MA) microbubbles have been measured using a calibrated microacoustic system, and a unique transient characteristic of resonance has been identified in the onset of scatter. Comparison of the numerically obtained response of microbubbles with acoustic measurements provides good agreement for a soft shell that is characterized by small area dilatation modulus and strain softening behavior, and identifies time to maximum radial excursion and scatter as a robust marker of resonance during transient response. As the sound amplitude increases a two-population pattern emerges in the time delay vs the fundamental acoustic scatter plots, consisting of an initial part pertaining to microbubbles with less than resonant rest radii, which corresponds to the weaker second harmonic resonance, and the dominant resonant envelope pertaining to microbubbles with resonant and greater than resonant rest radii, which corresponds to the primary and subharmonic resonances. Consequently, a wider resonant spectrum is observed. It is a result of the strain softening nature of soft lipid shells, based on which the microbubble sizes corresponding to the above resonances decrease as the sound amplitude increases. This bares an impact on the selection of an optimal microbubble size pertaining to subharmonic imaging. |
Author | Efthymiou, K Butler, M B Pelekasis, N Sboros, V Thomas, D H |
Author_xml | – sequence: 1 givenname: K surname: Efthymiou fullname: Efthymiou, K organization: Department of Mechanical Engineering, University of Thessally, Volos 38334, Greece – sequence: 2 givenname: N surname: Pelekasis fullname: Pelekasis, N organization: Department of Mechanical Engineering, University of Thessally, Volos 38334, Greece – sequence: 3 givenname: M B surname: Butler fullname: Butler, M B organization: Department of Physics, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom – sequence: 4 givenname: D H surname: Thomas fullname: Thomas, D H organization: University of California, Los Angeles (UCLA) Radiation Oncology, UCLA, Los Angeles, California 90095, USA – sequence: 5 givenname: V surname: Sboros fullname: Sboros, V organization: Department of Physics, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29604664$$D View this record in MEDLINE/PubMed |
BookMark | eNo1kEtLxDAUhYMozkMX_gHJH6gmaW-aupNhfMCAm3E93KY3WGmT0qQ-_r2V0dVZfIfDx1mxUx88MXYlxY2USt7KGxBKCyVP2FKCEpkBVSzYKsZ3IQSYvDpnC1VpUWhdLNnn_o04OUc28eD4SDF49JZ48DyN6GNLPvG-tWOop7ruiKMNU0yt_e0OwUe649uvgca2n5vY8VBHGj8wtTPj6Bvup36mdkax7afuSC7YmcMu0uVfrtnrw3a_ecp2L4_Pm_tdZnOAlOly1iRdaQvWCqmQJKAtoaiopKqAMpe5LCuTNw5N45QDA0YgFISy0UapNbs-7g5T3VNzGGZPHL8P_w-oHw8CXn8 |
CitedBy_id | crossref_primary_10_1039_D0SM00300J crossref_primary_10_1007_s10665_021_10144_0 crossref_primary_10_1038_s41598_023_40823_0 crossref_primary_10_1103_PhysRevFluids_6_013601 crossref_primary_10_1016_j_apacoust_2023_109792 crossref_primary_10_1103_PhysRevFluids_6_013602 crossref_primary_10_1103_PhysRevE_103_023108 |
ContentType | Journal Article |
DBID | NPM |
DOI | 10.1121/1.5026021 |
DatabaseName | PubMed |
DatabaseTitle | PubMed |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Physics |
EISSN | 1520-8524 |
ExternalDocumentID | 29604664 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GrantInformation_xml | – fundername: British Heart Foundation grantid: PG/10/21/28254 |
GroupedDBID | --- --Z -~X .DC .GJ 123 186 29L 3O- 4.4 41~ 5-Q 53G 5RE 5VS 6TJ 85S AAAAW AAEUA AAPUP AAYIH ABDNZ ABEFU ABJNI ABNAN ABPPZ ABTAH ABZEH ACBNA ACBRY ACCUC ACGFO ACGFS ACNCT ACXMS ACYGS ADCTM AEGXH AEILP AENEX AFFNX AFHCQ AGKCL AGLKD AGMXG AGTJO AGVCI AHPGS AHSDT AI. AIAGR AIDUJ AIZTS ALMA_UNASSIGNED_HOLDINGS AQWKA BAUXJ CS3 D0L DU5 EBS EJD ESX F5P G8K H~9 M71 M73 MVM NEJ NHB NPM OHT OK1 P2P RAZ RIP RNS ROL RQS S10 SC5 SJN TN5 TWZ UCJ UHB UPT UQL VH1 VOH VQA WH7 XJT XOL XSW YQT ZCG ZXP ZY4 ~02 ~G0 |
ID | FETCH-LOGICAL-c355t-67466e696c5cc012ae15ac7549e7e945731317983dfa8df2f58580a54ea1d6822 |
IngestDate | Sat Sep 28 08:25:40 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c355t-67466e696c5cc012ae15ac7549e7e945731317983dfa8df2f58580a54ea1d6822 |
PMID | 29604664 |
ParticipantIDs | pubmed_primary_29604664 |
PublicationCentury | 2000 |
PublicationDate | 2018-03-00 |
PublicationDateYYYYMMDD | 2018-03-01 |
PublicationDate_xml | – month: 03 year: 2018 text: 2018-03-00 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | The Journal of the Acoustical Society of America |
PublicationTitleAlternate | J Acoust Soc Am |
PublicationYear | 2018 |
SSID | ssj0005839 |
Score | 2.333505 |
Snippet | A large number of acoustic signals from single lipid-shelled Definity
(Lantheus Medical Imaging, N. Billerica, MA) microbubbles have been measured using a... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 1392 |
Title | The effect of resonance on transient microbubble acoustic response: Experimental observations and numerical simulations |
URI | https://www.ncbi.nlm.nih.gov/pubmed/29604664 |
Volume | 143 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1dS8MwFA1TEXwRv78lD75J5_qVpr6pKCJMfFDwTZo2AdG1wjYE_5B_03uTNItDRX0ppdnarvfs5iQ994SQgyqTgkNHGvBYwABFSthLExUwLqskUgX0MTgP2b9ml3fJ1X163-m8e6ql8Uh0y7cv60r-E1U4BnHFKtk_RNadFA7APsQXthBh2P46xkaQgZwPBs5NrSsA8AUA9kFY63g4QMmdGAsskYL0p1fvws-iNFYXpp_7Jv-NcNO0xr25Hpt3Os-Hw8eBXetr6FPaSXHZcys4OLGXQacRqwpFwmtO5Di8AowMHpvxp8nWG-gGn4qhcT5wr4lOUbaksdWfLBNttE06adoSCzt7EfKJfKsrbcaNEB6mkNqlZGPdZLEXewkWCGv0deaPMPOH3RRN0kzRtYeAl4GGQIRWNMzYpv_cOmXC3TbNkJmMYyK9xkmhVkkEJNOaVsFdHLl7QKNp-72pQYsmL7dLZNGGh54YCC2TjqxXyLxW_5bDVfIKMaQGSLRR1AGJNjV1QKIekGgLJNoC6Zj6MKI-jCjAiDoYUQ9Ga-Tu4vz27DKwK3IEJfDSUcAy-DGS5axMyxKoTSHDtCizNMllJvMkzeIwRge8uFIFr1SkYDDKe0WayCKsGHDRdTJbN7XcJDQUspfHKmcCDZCyXhEyXlWcKyFF2RP5FtkwT-zhxdiuPLTPcvvblh2yMMHYLplT8D-Xe0AaR2Jfh-wDM6Zxqg |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+effect+of+resonance+on+transient+microbubble+acoustic+response%3A+Experimental+observations+and+numerical+simulations&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.au=Efthymiou%2C+K&rft.au=Pelekasis%2C+N&rft.au=Butler%2C+M+B&rft.au=Thomas%2C+D+H&rft.date=2018-03-01&rft.eissn=1520-8524&rft.volume=143&rft.issue=3&rft.spage=1392&rft_id=info:doi/10.1121%2F1.5026021&rft_id=info%3Apmid%2F29604664&rft_id=info%3Apmid%2F29604664&rft.externalDocID=29604664 |