IGF2BP2: an m6A reader that affects cellular function and disease progression

• Published in: Cellular & molecular biology letters Vol. 30; no. 1; pp. 43 - 32
• Main Authors: Liu, Siyi, Liao, Shan, He, Junyu, Zhou, Yanhong, He, Qian
• Format: Journal Article
• Language: English
• Published: Wrocław BioMed Central 09.04.2025; BMC
• Subjects: Angiogenesis; Apoptosis; Binding sites; Cell stemness; Cells; Colon; Disease; Epithelial–mesenchymal transition; Esophageal cancer; Ferroptosis; Genes; Hypoxia; IGF2BP2; Inflammation; Inflammatory bowel disease; Lipid metabolism; Lipid peroxidation; Lipids; Metabolism; Metastasis; Molecular modelling; mRNA stability; N6-methyladenosine; Proteins; Review; RNA modification; Squamous cell carcinoma; Transcription factors; Tumors

Insulin-like growth factor 2 messenger RNA (mRNA)-binding protein 2 (IGF2BP2) is a widely studied N 6 -methyladenosine (m 6 A) modification reader, primarily functioning to recognize and bind to m 6 A modification sites on the mRNA of downstream target genes, thereby enhancing their stability. Previ...