Rab27b regulates c-kit expression by controlling the secretion of stem cell factor

• Published in: Biochemical and biophysical research communications Vol. 419; no. 2; pp. 368 - 373
• Main Authors: Tanaka, Chisato, Kaji, Hiroaki, He, Jinsong, Hazama, Ryoichi, Yokoyama, Kunio, Kinoshita, Emi, Tsujioka, Takayuki, Tohyama, Kaoru, Yamamura, Hirohei, Nishio, Hisahide, Tohyama, Yumi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.03.2012
• Subjects: Autocrine Communication; c-Kit; Cell Line, Tumor; Cell Membrane - metabolism; Gene Knockdown Techniques; Humans; Lysosome; Lysosomes - metabolism; Proteolysis; Proto-Oncogene Proteins c-kit - biosynthesis; Proto-Oncogene Proteins c-kit - metabolism; rab GTP-Binding Proteins - genetics; rab GTP-Binding Proteins - metabolism; Rab27b; SCF; Stem Cell Factor - metabolism; Up-Regulation; Rab27b; c-Kit; Lysosome; SCF

► Rab27b negatively regulates c-kit expression in megakaryocytic lineage cells. ► c-kit is degraded by SCF-induced endolysosomal pathway. ► Rab27b regulates autocrine secretion of SCF and leads to c-kit degradation. Rab27b, a subfamily of Rab27 small GTPases, was originally identified in platelets....