Metabolic abnormality in the right dorsolateral prefrontal cortex in patients with obsessive–compulsive disorder: proton magnetic resonance spectroscopy
Proton magnetic resonance spectroscopy (1H-MRS) was used to evaluate metabolic changes in the dorsolateral prefrontal cortex (DLPFC) in patients with obsessive-compulsive disorder (OCD). In total, 14 OCD patients (mean age 28.9±7.2 years) and 14 healthy controls (mean age 32.6±7.1 years) with no his...
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| Published in | Acta neuropsychiatrica Vol. 29; no. 3; pp. 164 - 169 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English Dutch |
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Cambridge, UK
Cambridge University Press
01.06.2017
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| Abstract | Proton magnetic resonance spectroscopy (1H-MRS) was used to evaluate metabolic changes in the dorsolateral prefrontal cortex (DLPFC) in patients with obsessive-compulsive disorder (OCD).
In total, 14 OCD patients (mean age 28.9±7.2 years) and 14 healthy controls (mean age 32.6±7.1 years) with no history of neurological and psychiatric illness participated in this study. Brain metabolite concentrations were measured from a localised voxel on the right DLPFC using a 3-Tesla 1H-MRS.
The metabolic concentration of myo-inositol in patients with OCD increased significantly by 52% compared with the healthy controls, whereas glutamine/glutamate was decreased by 11%. However, there were no significant differences in N-acetylaspartate, choline, lactate and lipid between the two groups.
These findings would be helpful to understand the pathophysiology of OCD associated with the brain metabolic abnormalities in the right DLPFC. |
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| AbstractList | Objective
Proton magnetic resonance spectroscopy (
1
H-MRS) was used to evaluate metabolic changes in the dorsolateral prefrontal cortex (DLPFC) in patients with obsessive–compulsive disorder (OCD).
Methods
In total, 14 OCD patients (mean age 28.9±7.2 years) and 14 healthy controls (mean age 32.6±7.1 years) with no history of neurological and psychiatric illness participated in this study. Brain metabolite concentrations were measured from a localised voxel on the right DLPFC using a 3-Tesla
1
H-MRS.
Results
The metabolic concentration of
myo
-inositol in patients with OCD increased significantly by 52% compared with the healthy controls, whereas glutamine/glutamate was decreased by 11%. However, there were no significant differences in
N
-acetylaspartate, choline, lactate and lipid between the two groups.
Conclusion
These findings would be helpful to understand the pathophysiology of OCD associated with the brain metabolic abnormalities in the right DLPFC. OBJECTIVEProton magnetic resonance spectroscopy (1H-MRS) was used to evaluate metabolic changes in the dorsolateral prefrontal cortex (DLPFC) in patients with obsessive-compulsive disorder (OCD).METHODSIn total, 14 OCD patients (mean age 28.9±7.2 years) and 14 healthy controls (mean age 32.6±7.1 years) with no history of neurological and psychiatric illness participated in this study. Brain metabolite concentrations were measured from a localised voxel on the right DLPFC using a 3-Tesla 1H-MRS.RESULTSThe metabolic concentration of myo-inositol in patients with OCD increased significantly by 52% compared with the healthy controls, whereas glutamine/glutamate was decreased by 11%. However, there were no significant differences in N-acetylaspartate, choline, lactate and lipid between the two groups.CONCLUSIONThese findings would be helpful to understand the pathophysiology of OCD associated with the brain metabolic abnormalities in the right DLPFC. Proton magnetic resonance spectroscopy (1H-MRS) was used to evaluate metabolic changes in the dorsolateral prefrontal cortex (DLPFC) in patients with obsessive-compulsive disorder (OCD). In total, 14 OCD patients (mean age 28.9±7.2 years) and 14 healthy controls (mean age 32.6±7.1 years) with no history of neurological and psychiatric illness participated in this study. Brain metabolite concentrations were measured from a localised voxel on the right DLPFC using a 3-Tesla 1H-MRS. The metabolic concentration of myo-inositol in patients with OCD increased significantly by 52% compared with the healthy controls, whereas glutamine/glutamate was decreased by 11%. However, there were no significant differences in N-acetylaspartate, choline, lactate and lipid between the two groups. These findings would be helpful to understand the pathophysiology of OCD associated with the brain metabolic abnormalities in the right DLPFC. |
| Author | Jeong, Gwang-Woo Choi, Nam-Gil Park, Shin-Eui |
| Author_xml | – sequence: 1 givenname: Shin-Eui surname: Park fullname: Park, Shin-Eui organization: Interdisciplinary Program of Biomedical Engineering, Chonnam National University, Gwangju, Republic of Korea – sequence: 2 givenname: Nam-Gil surname: Choi fullname: Choi, Nam-Gil organization: Department of Radiology, DongShin University, Naju, Republic of Korea – sequence: 3 givenname: Gwang-Woo surname: Jeong fullname: Jeong, Gwang-Woo email: gwjeong@jnu.ac.kr organization: Interdisciplinary Program of Biomedical Engineering, Chonnam National University, Gwangju, Republic of Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27748207$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_jocrd_2020_100523 crossref_primary_10_1017_neu_2018_7 crossref_primary_10_1016_j_brainres_2024_148852 crossref_primary_10_1017_S0033291719001429 crossref_primary_10_1002_brb3_3333 crossref_primary_10_1016_j_pscychresns_2017_08_010 crossref_primary_10_1016_j_inffus_2020_07_006 crossref_primary_10_4103_indianjpsychiatry_indianjpsychiatry_663_23 crossref_primary_10_1080_08039488_2016_1265584 crossref_primary_10_1016_j_neulet_2019_134449 crossref_primary_10_1016_j_brainresbull_2023_04_004 crossref_primary_10_4103_1673_5374_387969 |
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| Keywords | obsessive–compulsive disorder (OCD) dorsolateral prefrontal cortex (DLPFC) proton magnetic resonance spectroscopy (1H-MRS) |
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| SubjectTerms | Adult Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Brain Brain - diagnostic imaging Brain - metabolism Choline - metabolism Education Female Gender Glutamic Acid - metabolism Glutamine - metabolism Humans Inositol - metabolism Lactic Acid - metabolism Male Mental disorders Metabolism Metabolites Neuroimaging - methods Obsessive compulsive disorder Obsessive-Compulsive Disorder - metabolism Original Articles Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - metabolism Prefrontal Cortex - physiopathology Proton Magnetic Resonance Spectroscopy - methods Spectrum analysis Young Adult |
| Title | Metabolic abnormality in the right dorsolateral prefrontal cortex in patients with obsessive–compulsive disorder: proton magnetic resonance spectroscopy |
| URI | https://www.cambridge.org/core/product/identifier/S092427081600048X/type/journal_article https://www.ncbi.nlm.nih.gov/pubmed/27748207 https://www.proquest.com/docview/2788635823 https://search.proquest.com/docview/1835437430 |
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