Depletion of a Toxoplasma porin leads to defects in mitochondrial morphology and contacts with the endoplasmic reticulum

• Published in: Journal of cell science Vol. 134; no. 20
• Main Authors: Mallo, Natalia, Ovciarikova, Jana, Martins-Duarte, Erica S., Baehr, Stephan C., Biddau, Marco, Wilde, Mary-Louise, Uboldi, Alessandro D., Lemgruber, Leandro, Tonkin, Christopher J., Wideman, Jeremy G., Harding, Clare R., Sheiner, Lilach
• Format: Journal Article
• Language: English
• Published: The Company of Biologists Ltd 15.10.2021
• Subjects: Mitochondria

The voltage-dependent anion channel (VDAC) is a ubiquitous channel in the outer membrane of the mitochondrion with multiple roles in protein, metabolite and small molecule transport. In mammalian cells, VDAC protein, as part of a larger complex including the inositol triphosphate receptor, has been...