Synthetic growth hormone secretagogues control growth hormone secretion in the chicken at pituitary and hypothalamic levels
In the chicken growth hormone (GH) secretion is predominantly controlled by two hormones, thyrotropin-releasing hormone (TRH) and somatostatin (SRIH), respectively stimulating and inhibiting GH release. In view of the hypothesis of a novel GH secretagogue (GHS) in mammals, this specific species was...
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Published in | Endocrine Vol. 14; no. 1; pp. 67 - 72 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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United States
01.02.2001
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Abstract | In the chicken growth hormone (GH) secretion is predominantly controlled by two hormones, thyrotropin-releasing hormone (TRH) and somatostatin (SRIH), respectively stimulating and inhibiting GH release. In view of the hypothesis of a novel GH secretagogue (GHS) in mammals, this specific species was used to further assess the exact function of two nonpeptidyl GHSs-L-692,429 and L-163,255. Both synthetic products stimulate GH secretion directly at the level of the pituitary as shown in in vitro perifusion studies. Plasma GH levels increase within 10-15 min after a single challenge of L-692,429 or L-163,255. A SRIH pretreatment dimishes this GH response. Both GH-releasing peptide mimetics decrease hypothalamic TRH concentrations, whereas SRIH levels are not affected. The novel GHS may therefore control GH secretion both at the level of the pituitary and the hypothalamus. The present article shows that nonpeptidyl mimetics also control GH secretion in nonmammalian species suggesting that the endogenous hormone may be a conserved GH stimulator in several vertebrates. The GH response to GHS in birds may be regulated both directly at the level of the pituitary and by releasing another endogenous GH stimulator (TRH) from the hypothalamus. |
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AbstractList | In the chicken growth hormone (GH) secretion is predominantly controlled by two hormones, thyrotropin-releasing hormone (TRH) and somatostatin (SRIH), respectively stimulating and inhibiting GH release. In view of the hypothesis of a novel GH secretagogue (GHS) in mammals, this specific species was used to further assess the exact function of two nonpeptidyl GHSs-L-692,429 and L-163,255. Both synthetic products stimulate GH secretion directly at the level of the pituitary as shown in in vitro perifusion studies. Plasma GH levels increase within 10-15 min after a single challenge of L-692,429 or L-163,255. A SRIH pretreatment dimishes this GH response. Both GH-releasing peptide mimetics decrease hypothalamic TRH concentrations, whereas SRIH levels are not affected. The novel GHS may therefore control GH secretion both at the level of the pituitary and the hypothalamus. The present article shows that nonpeptidyl mimetics also control GH secretion in nonmammalian species suggesting that the endogenous hormone may be a conserved GH stimulator in several vertebrates. The GH response to GHS in birds may be regulated both directly at the level of the pituitary and by releasing another endogenous GH stimulator (TRH) from the hypothalamus. |
Author | Darras, V M Hickey, G J Kühn, E R Vanderghote, A Geris, K L |
Author_xml | – sequence: 1 givenname: K L surname: Geris fullname: Geris, K L email: kris.geris@bio.kuleuven.ac.be organization: Laboratory of Comparative Endocrinology, Leuven, Belgium. kris.geris@bio.kuleuven.ac.be – sequence: 2 givenname: G J surname: Hickey fullname: Hickey, G J – sequence: 3 givenname: A surname: Vanderghote fullname: Vanderghote, A – sequence: 4 givenname: E R surname: Kühn fullname: Kühn, E R – sequence: 5 givenname: V M surname: Darras fullname: Darras, V M |
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SubjectTerms | Animals Benzazepines - administration & dosage Benzazepines - pharmacology Chickens Growth Hormone - blood Growth Hormone - secretion Hormones - administration & dosage Hormones - pharmacology Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - secretion In Vitro Techniques Piperidines - administration & dosage Piperidines - pharmacology Pituitary Gland - drug effects Pituitary Gland - secretion Spiro Compounds - administration & dosage Spiro Compounds - pharmacology Tetrazoles - administration & dosage Tetrazoles - pharmacology Thyrotropin-Releasing Hormone - blood Thyrotropin-Releasing Hormone - secretion Up-Regulation |
Title | Synthetic growth hormone secretagogues control growth hormone secretion in the chicken at pituitary and hypothalamic levels |
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