Beyond the blur: Scopolamine's utility and limits in modeling cognitive disorders across sexes – Narrative review

• Published in: Ageing research reviews Vol. 104; p. 102635
• Main Authors: Jagielska, Angelika, Sałaciak, Kinga, Pytka, Karolina
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.02.2025
• Subjects: Animal Model; Animals; Cognition - drug effects; Cognition Disorders - chemically induced; Cognitive Dysfunction - chemically induced; Disease Models, Animal; Executive Functions; Female; Humans; Male; Memory; Muscarinic Antagonists - pharmacology; Scopolamine; Scopolamine - adverse effects; Scopolamine - pharmacology; Sex differences; Sex Factors; Sex differences; Scopolamine; Animal Model; Memory; Executive Functions

Scopolamine, widely regarded as the gold standard in preclinical studies of memory impairments, acts as a non-selective antagonist of central and peripheral muscarinic receptors. While its application in modeling dementia primarily involves antagonism at the M1 receptor, its non-selective peripheral...