Epidermal CYP2 family cytochromes P450

• Published in: Toxicology and applied pharmacology Vol. 195; no. 3; pp. 278 - 287
• Main Authors: Du, Liping, Hoffman, Susan M G, Keeney, Diane S
• Format: Journal Article
• Language: English
• Published: United States 15.03.2004
• Subjects: Animals; Cytochrome P-450 Enzyme System - biosynthesis; Cytochrome P-450 Enzyme System - genetics; Gene Expression Regulation, Enzymologic; Humans; Skin - enzymology; Transcription, Genetic

Skin is the largest and most accessible drug-metabolizing organ. In mammals, it is the competent barrier that protects against exposure to harmful stimuli in the environment and in the systemic circulation. Skin expresses many cytochromes P450 that have critical roles in exogenous and endogenous sub...