Role of arginine in superficial wound healing in man
Arginine supplementation has been identified as advantageous in experimental wound healing. However, the mechanisms underlying this beneficial effect in tissue repair remain unresolved. Animal studies suggest that the beneficial role of arginine supplementation is mediated, at least in part through...
Saved in:
Published in | Nitric oxide Vol. 21; no. 3; pp. 175 - 183 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.11.2009
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Arginine supplementation has been identified as advantageous in experimental wound healing. However, the mechanisms underlying this beneficial effect in tissue repair remain unresolved. Animal studies suggest that the beneficial role of arginine supplementation is mediated, at least in part through NO. The latter component mediates processes involved in tissue repair, including angiogenesis, epithelialization and collagen formation. This prospective study is performed to investigate arginine metabolism in acute surgical wounds in man. Expression of enzymes, known to be involved in arginine metabolism, was studied in donor sites of skin grafts of 10 hospitalized patients undergoing skin transplantation. Plasma and wound fluid levels of arginine metabolites (ornithine, citrulline, nitrate and nitrite
=
NOx) were measured using High Performance Liquid Chromatography. Expression of iNOS, eNOS, arginase-1 and arginase-2 was studied by immunohistochemistry in paraffin sections of skin tissue. Arginase-1 concentration was measured in plasma and wound fluid using ELISA. Arginase-2 was determined using Western blot analysis. We observed increased levels of citrulline, ornithine, NOx and arginase-1 in wound fluid when compared with plasma. Arginase-2 was expressed in both plasma and wound fluid and seemed higher in plasma. iNOS was expressed by neutrophils, macrophages, fibroblasts, keratinocytes and endothelial cells upon wounding, whereas eNOS reactivity was observed in endothelial cells and fibroblasts. Arginase-1 was expressed in neutrophils post-wounding, while arginase-2 staining was observed in endothelial cells, keratinocytes, fibroblasts, macrophages and neutrophils. For the first time, human data support previous animal studies suggesting arginine metabolism for an NO- as well as arginase-mediated reparation of injured skin. |
---|---|
AbstractList | Arginine supplementation has been identified as advantageous in experimental wound healing. However, the mechanisms underlying this beneficial effect in tissue repair remain unresolved. Animal studies suggest that the beneficial role of arginine supplementation is mediated, at least in part through NO. The latter component mediates processes involved in tissue repair, including angiogenesis, epithelialization and collagen formation. This prospective study is performed to investigate arginine metabolism in acute surgical wounds in man. Expression of enzymes, known to be involved in arginine metabolism, was studied in donor sites of skin grafts of 10 hospitalized patients undergoing skin transplantation. Plasma and wound fluid levels of arginine metabolites (ornithine, citrulline, nitrate and nitrite = NOx) were measured using High Performance Liquid Chromatography. Expression of iNOS, eNOS, arginase-1 and arginase-2 was studied by immunohistochemistry in paraffin sections of skin tissue. Arginase-1 concentration was measured in plasma and wound fluid using ELISA. Arginase-2 was determined using Western blot analysis. We observed increased levels of citrulline, ornithine, NOx and arginase-1 in wound fluid when compared with plasma. Arginase-2 was expressed in both plasma and wound fluid and seemed higher in plasma. iNOS was expressed by neutrophils, macrophages, fibroblasts, keratinocytes and endothelial cells upon wounding, whereas eNOS reactivity was observed in endothelial cells and fibroblasts. Arginase-1 was expressed in neutrophils post-wounding, while arginase-2 staining was observed in endothelial cells, keratinocytes, fibroblasts, macrophages and neutrophils. For the first time, human data support previous animal studies suggesting arginine metabolism for an NO- as well as arginase-mediated reparation of injured skin. Arginine supplementation has been identified as advantageous in experimental wound healing. However, the mechanisms underlying this beneficial effect in tissue repair remain unresolved. Animal studies suggest that the beneficial role of arginine supplementation is mediated, at least in part through NO. The latter component mediates processes involved in tissue repair, including angiogenesis, epithelialization and collagen formation. This prospective study is performed to investigate arginine metabolism in acute surgical wounds in man. Expression of enzymes, known to be involved in arginine metabolism, was studied in donor sites of skin grafts of 10 hospitalized patients undergoing skin transplantation. Plasma and wound fluid levels of arginine metabolites (ornithine, citrulline, nitrate and nitrite = NOx) were measured using High Performance Liquid Chromatography. Expression of iNOS, eNOS, arginase-1 and arginase-2 was studied by immunohistochemistry in paraffin sections of skin tissue. Arginase-1 concentration was measured in plasma and wound fluid using ELISA. Arginase-2 was determined using Western blot analysis. We observed increased levels of citrulline, ornithine, NOx and arginase-1 in wound fluid when compared with plasma. Arginase-2 was expressed in both plasma and wound fluid and seemed higher in plasma. iNOS was expressed by neutrophils, macrophages, fibroblasts, keratinocytes and endothelial cells upon wounding, whereas eNOS reactivity was observed in endothelial cells and fibroblasts. Arginase-1 was expressed in neutrophils post-wounding, while arginase-2 staining was observed in endothelial cells, keratinocytes, fibroblasts, macrophages and neutrophils. For the first time, human data support previous animal studies suggesting arginine metabolism for an NO- as well as arginase-mediated reparation of injured skin. |
Author | van der Hulst, R.R.W.J. Cleutjens, J.P.M. Peutz-Kootstra, C.J. Gotoh, T. Debats, I.B.J.G. Wolfs, T.G.A.M. |
Author_xml | – sequence: 1 givenname: I.B.J.G. surname: Debats fullname: Debats, I.B.J.G. organization: Department of Plastic, Reconstructive and Handsurgery, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands – sequence: 2 givenname: T.G.A.M. surname: Wolfs fullname: Wolfs, T.G.A.M. organization: Department of General Surgery, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands – sequence: 3 givenname: T. surname: Gotoh fullname: Gotoh, T. organization: Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Kumamoto 860-8556, Japan – sequence: 4 givenname: J.P.M. surname: Cleutjens fullname: Cleutjens, J.P.M. organization: Department of Pathology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands – sequence: 5 givenname: C.J. surname: Peutz-Kootstra fullname: Peutz-Kootstra, C.J. organization: Department of Pathology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands – sequence: 6 givenname: R.R.W.J. surname: van der Hulst fullname: van der Hulst, R.R.W.J. email: RVH@spch.azm.nl organization: Department of Plastic, Reconstructive and Handsurgery, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19638312$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kE1LAzEQhoNU7If-AQ-yN09dJ0mT7IIXKX5BQRA9h2x2tqZsk5p0_fj3bmnRm6cZmOd9YZ4xGfjgkZBzCjkFKq9WuXfhK2cAZQ4qB5BHZEShKKeFpHTwuwMfknFKKwCY8UKekCEtJS84ZSMyew4tZqHJTFw67zxmzmep22BsnHWmzT5D5-vsDU3r_HJ3XBt_So4b0yY8O8wJeb27fZk_TBdP94_zm8XUciG2U4bCMs5LpipZKTVjUgijTF1QAaqwVFRcGslZJYBBU4EylbINUmUNpYVAPiGX-95NDO8dpq1eu2SxbY3H0CWtOJdUUFX2JNuTNoaUIjZ6E93axG9NQe9k6ZXeydI7WRqU7mX1oYtDfVetsf6LHOz0wPUewP7JD4dRJ-vQW6xdRLvVdXD_9f8AuVF7Cw |
CitedBy_id | crossref_primary_10_1002_eji_201141683 crossref_primary_10_1016_j_jss_2014_01_041 crossref_primary_10_2144_fsoa_2021_0014 crossref_primary_10_3389_fphys_2017_00682 crossref_primary_10_1177_15347346211012381 crossref_primary_10_1152_ajpregu_00003_2012 crossref_primary_10_1088_2057_1976_ab756f crossref_primary_10_3389_fendo_2022_927224 crossref_primary_10_3390_nu11092129 crossref_primary_10_4028_www_scientific_net_KEM_829_203 crossref_primary_10_1089_wound_2014_0530 crossref_primary_10_3390_ijms18020245 crossref_primary_10_1038_jid_2013_164 crossref_primary_10_1177_1534734617737639 crossref_primary_10_1111_wrr_13009 crossref_primary_10_18632_oncotarget_16533 crossref_primary_10_1089_wound_2020_1215 crossref_primary_10_1177_0218492313484025 crossref_primary_10_1007_s00726_013_1486_0 crossref_primary_10_12968_indn_2023_4_16 crossref_primary_10_1088_1748_605X_ab12b3 crossref_primary_10_1089_neu_2022_0271 crossref_primary_10_1089_wound_2012_0415 crossref_primary_10_1002_eji_201041105 crossref_primary_10_1177_000348941112000706 crossref_primary_10_1016_j_actbio_2017_01_039 crossref_primary_10_1111_j_1742_481X_2012_01120_x crossref_primary_10_3390_polym10060607 crossref_primary_10_1097_GOX_0000000000003314 crossref_primary_10_1038_s41598_017_12435_y crossref_primary_10_1016_j_jtcvs_2020_06_016 crossref_primary_10_1093_eurheartj_eht329 crossref_primary_10_1038_s41392_021_00830_x crossref_primary_10_1186_s42826_019_0025_x crossref_primary_10_2106_JBJS_RVW_17_00071 crossref_primary_10_1007_s11010_012_1433_5 crossref_primary_10_1111_wrr_12048 crossref_primary_10_1016_j_ijbiomac_2020_12_025 crossref_primary_10_1097_PAS_0b013e3181e5dffa crossref_primary_10_3109_13880209_2014_936470 crossref_primary_10_1097_PRS_0000000000007004 crossref_primary_10_1016_j_fsi_2020_06_026 crossref_primary_10_3390_polym13081291 crossref_primary_10_1016_j_ijbiomac_2021_10_166 crossref_primary_10_1016_j_nut_2012_01_013 crossref_primary_10_1007_s11306_017_1218_7 crossref_primary_10_29252_mlj_11_6_7 crossref_primary_10_1016_j_ijbiomac_2019_08_095 crossref_primary_10_3390_ijms20051119 crossref_primary_10_1016_j_wndm_2016_07_002 crossref_primary_10_1155_2015_687694 crossref_primary_10_3389_fimmu_2014_00479 crossref_primary_10_1016_j_eurpolymj_2019_05_020 crossref_primary_10_1111_pcmr_12605 crossref_primary_10_1007_s12035_018_1295_2 crossref_primary_10_32345_USMYJ_2_131__2022_61_69 crossref_primary_10_1152_ajprenal_00340_2015 crossref_primary_10_1177_0884533617691250 crossref_primary_10_1016_j_lfs_2015_07_012 crossref_primary_10_3390_nu15020352 crossref_primary_10_1292_jvms_22_0335 crossref_primary_10_3389_fimmu_2020_00938 crossref_primary_10_1038_ncomms4562 crossref_primary_10_3390_ijms22020508 crossref_primary_10_3945_ajcn_110_009209 crossref_primary_10_1007_s00210_023_02667_3 crossref_primary_10_1016_j_ajpath_2010_08_003 crossref_primary_10_1177_0148607111414579 crossref_primary_10_1097_CCM_0000000000001640 crossref_primary_10_1038_s41598_024_54352_x crossref_primary_10_1007_s13346_020_00857_7 crossref_primary_10_1002_jcp_29812 crossref_primary_10_1097_PRS_0b013e318201256c crossref_primary_10_1371_journal_pntd_0001684 |
Cites_doi | 10.1097/00003246-200203000-00003 10.1016/0006-291X(89)92506-0 10.1093/jn/138.10.2021S 10.1111/j.1440-1681.2007.04638.x 10.1097/BCR.0b013e3181a28c15 10.1111/j.1743-6109.2006.00151.x 10.1006/jsre.2001.6168 10.1016/S0002-9440(10)65362-X 10.1146/annurev.nu.12.070192.000501 10.1097/00005373-200109000-00012 10.1096/fj.04-2317fje 10.1042/bj3360001 10.1152/ajpendo.2001.280.1.E75 10.1016/S0024-3205(00)00836-5 10.1177/000456329703400212 10.1016/j.jss.2007.10.015 10.1080/110241599750007153 10.1006/jsre.2002.6443 10.1083/jcb.144.3.427 10.1097/00000658-200209000-00013 10.1016/S1357-2725(02)00028-6 10.1093/jn/137.6.1616S 10.1006/jsre.2001.6261 10.1038/nri1668 10.1096/fj.00-0681fje 10.1007/s726-002-8200-9 10.1152/ajpcell.1998.274.1.C236 10.1016/0379-0738(90)90311-L 10.1016/S1471-4906(03)00132-7 10.1016/S0002-9440(10)63297-X 10.1016/S0002-9610(02)00815-2 10.1006/jsre.1997.5137 10.1016/j.niox.2006.04.002 10.1046/j.1523-1747.2003.12610.x 10.1097/01.tp.0000226067.89690.2b 10.1016/S0009-9120(01)00254-5 10.1046/j.1523-1747.1998.00434.x 10.1097/00000658-200103000-00014 10.1016/S0002-9440(10)63811-4 10.1146/annurev.bi.49.070180.005041 10.1016/0261-5614(94)90028-0 10.1067/msy.2001.115837 10.1067/msy.2002.127422 10.1007/s001250051224 10.1016/S1091-255X(02)00431-6 10.1016/j.niox.2009.01.005 10.1073/pnas.041359198 10.1001/archderm.116.11.1225 10.1002/1096-9896(2000)9999:9999<::AID-PATH654>3.0.CO;2-S 10.1006/bbrc.1998.8681 10.1111/j.1346-8138.1997.tb02748.x 10.1097/00063110-200112000-00012 10.1016/j.yjmcc.2004.05.004 10.1007/BF02236217 10.1016/0022-3468(91)90840-P 10.1128/IAI.63.7.2793-2796.1995 10.1097/00075197-200303000-00012 10.1182/blood-2006-11-010389 10.1006/jsre.1996.0254 10.1006/bbrc.1994.1364 10.1067/msy.2001.111700 10.1152/ajpcell.1999.276.6.C1271 10.1182/blood-2006-06-032599 10.1159/000049388 10.1006/jsre.1993.1114 10.1111/1523-1747.ep12343428 10.1152/ajpregu.2000.279.6.R2237 10.4049/jimmunol.144.10.3877 10.1097/00006534-199493030-00020 |
ContentType | Journal Article |
Copyright | 2009 Elsevier Inc. |
Copyright_xml | – notice: 2009 Elsevier Inc. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.niox.2009.07.006 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology Chemistry Biology |
EISSN | 1089-8611 |
EndPage | 183 |
ExternalDocumentID | 10_1016_j_niox_2009_07_006 19638312 S1089860309001001 |
Genre | Journal Article |
GroupedDBID | --- --K --M -~X .55 .GJ .~1 0R~ 123 1B1 1RT 1~. 1~5 29N 3O- 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABFNM ABGSF ABMAC ABUDA ABXDB ABYKQ ACDAQ ACGFS ACRLP ADBBV ADEZE ADFGL ADMUD ADUVX AEBSH AEHWI AEKER AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHPSJ AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CAG COF CS3 DM4 DOVZS EBS EFBJH EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-Q GBLVA HVGLF HZ~ H~9 IHE J1W KOM LG5 M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SES SEW SPCBC SSU SSZ T5K WH7 X7M XPP ZGI ZU3 ~G- AAXKI AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c355t-2e5c233927b6b7742655a7ad815078c15b36a632b5020fb07ab7cfe17ca1185e3 |
IEDL.DBID | .~1 |
ISSN | 1089-8603 |
IngestDate | Fri Oct 25 10:14:59 EDT 2024 Thu Sep 26 17:58:31 EDT 2024 Sat Sep 28 08:33:54 EDT 2024 Fri Feb 23 02:22:50 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Keywords | Human Wound healing NOS Arginine Nitric oxide Arginase Acute wounds |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c355t-2e5c233927b6b7742655a7ad815078c15b36a632b5020fb07ab7cfe17ca1185e3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 19638312 |
PQID | 733615179 |
PQPubID | 23479 |
PageCount | 9 |
ParticipantIDs | proquest_miscellaneous_733615179 crossref_primary_10_1016_j_niox_2009_07_006 pubmed_primary_19638312 elsevier_sciencedirect_doi_10_1016_j_niox_2009_07_006 |
PublicationCentury | 2000 |
PublicationDate | 2009-11-01 |
PublicationDateYYYYMMDD | 2009-11-01 |
PublicationDate_xml | – month: 11 year: 2009 text: 2009-11-01 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Nitric oxide |
PublicationTitleAlternate | Nitric Oxide |
PublicationYear | 2009 |
Publisher | Elsevier Inc |
Publisher_xml | – name: Elsevier Inc |
References | Markert, Carnal, Mauel (bib43) 1994; 199 Kapoor (bib56) 2004; 165 Gotoh, Mori (bib77) 1999; 144 Mullner, Lazar, Hrabak (bib48) 2002; 34 Munder (bib69) 2006; 108 Williams, Abumrad, Barbul (bib33) 2002; 236 Xu (bib79) 2004; 18 Jacobsen (bib74) 2007; 109 Corraliza, Moncada (bib15) 2002; 29 Debats (bib29) 2009; 30 Efron (bib37) 2001; 98 Zunic (bib39) 2009; 20 Jablonska (bib44) 2005; 53 Wohlrab, Siemes, Marsch (bib81) 2002; 15 van Eijk, Dejong, Deutz, Soeters (bib31) 1994; 13 Barbul (bib9) 1990; 108 Mori (bib28) 2007; 137 Witte (bib78) 2003; 7 Durante, Johnson, Johnson (bib66) 2007; 34 Nirgiotis, Hennessey, Andrassy (bib8) 1991; 26 Bruch-Gerharz (bib68) 2003; 162 Fukumura (bib57) 2001; 98 Kepka-Lenhart (bib75) 2000; 279 Zhang (bib65) 2001; 15 Bansal, Ochoa (bib26) 2003; 6 Lesiewicz, Goldsmith (bib22) 1980; 116 Seifter (bib36) 1978; 84 Bronte, Zanovello (bib46) 2005; 5 Curran, Winter, Bouchier-Hayes (bib1) 2006; 14 Norris (bib5) 1995; 63 Albina (bib14) 1990; 144 Bronte (bib27) 2003; 24 Ochoa (bib72) 2001; 233 Nolan (bib45) 2007 Arbss (bib12) 2000; 67 Wu, Morris (bib24) 1998; 336 Pollock (bib3) 2001; 129 Bachetti (bib80) 2004; 37 Shi (bib54) 2001; 130 Rotondo (bib70) 2009; 1 Dolynchuk, Bendor-Samuel, Bowness (bib21) 1994; 93 Muhling (bib50) 2002; 22 Maeno (bib23) 1990; 46 Wang (bib55) 1996; 106 Tsuei (bib71) 2001; 51 Schaffer (bib4) 1997; 71 Jude (bib16) 1999; 42 Most (bib60) 2002; 132 Thornton (bib53) 1998; 246 Goligorsky (bib59) 1999; 276 Morris, Kepka-Lenhart, Chen (bib76) 1998; 275 Morris (bib18) 1992; 12 Wright (bib42) 1989; 160 Adams, Frank (bib19) 1980; 49 Albina, Abate, Mastrofrancesco (bib20) 1993; 55 Ikemoto (bib32) 2001; 34 Holan (bib67) 2006; 81 Shimizu (bib61) 1997; 24 Moncada, Palmer, Higgs (bib49) 1991; 43 Noiri (bib58) 1998; 274 Kirk (bib10) 1993; 114 Schaffer (bib38) 1996; 63 Schaffer (bib7) 1997; 184 Schaffer (bib52) 1999; 165 Frank (bib62) 1998; 111 Shashidharan (bib11) 1999; 42 Li (bib73) 2001; 280 Canturk (bib51) 2001; 8 Albina (bib34) 1988; 254 Chang, Liao, Kuo (bib64) 1998; 274 Abd-El-Aleem (bib13) 2000; 191 Lee (bib35) 2001; 101 Kampfer, Pfeilschifter, Frank (bib17) 2003; 121 Witte (bib25) 2002; 105 Bruins (bib6) 2002; 30 Amadeu (bib41) 2008; 149 Barbul (bib63) 2008; 138 Witte, Barbul (bib2) 2002; 183 Giovannoni (bib30) 1997; 34 Reichner (bib47) 1999; 154 Weller, Finnen (bib40) 2006; 15 Fukumura (10.1016/j.niox.2009.07.006_bib57) 2001; 98 Wu (10.1016/j.niox.2009.07.006_bib24) 1998; 336 Goligorsky (10.1016/j.niox.2009.07.006_bib59) 1999; 276 Bachetti (10.1016/j.niox.2009.07.006_bib80) 2004; 37 Kampfer (10.1016/j.niox.2009.07.006_bib17) 2003; 121 Bronte (10.1016/j.niox.2009.07.006_bib27) 2003; 24 Ikemoto (10.1016/j.niox.2009.07.006_bib32) 2001; 34 Debats (10.1016/j.niox.2009.07.006_bib29) 2009; 30 Adams (10.1016/j.niox.2009.07.006_bib19) 1980; 49 Bansal (10.1016/j.niox.2009.07.006_bib26) 2003; 6 Mullner (10.1016/j.niox.2009.07.006_bib48) 2002; 34 Wang (10.1016/j.niox.2009.07.006_bib55) 1996; 106 Jacobsen (10.1016/j.niox.2009.07.006_bib74) 2007; 109 Amadeu (10.1016/j.niox.2009.07.006_bib41) 2008; 149 Li (10.1016/j.niox.2009.07.006_bib73) 2001; 280 Schaffer (10.1016/j.niox.2009.07.006_bib7) 1997; 184 Arbss (10.1016/j.niox.2009.07.006_bib12) 2000; 67 Morris (10.1016/j.niox.2009.07.006_bib76) 1998; 275 Wohlrab (10.1016/j.niox.2009.07.006_bib81) 2002; 15 Jude (10.1016/j.niox.2009.07.006_bib16) 1999; 42 van Eijk (10.1016/j.niox.2009.07.006_bib31) 1994; 13 Weller (10.1016/j.niox.2009.07.006_bib40) 2006; 15 Bruch-Gerharz (10.1016/j.niox.2009.07.006_bib68) 2003; 162 Jablonska (10.1016/j.niox.2009.07.006_bib44) 2005; 53 Dolynchuk (10.1016/j.niox.2009.07.006_bib21) 1994; 93 Witte (10.1016/j.niox.2009.07.006_bib25) 2002; 105 Muhling (10.1016/j.niox.2009.07.006_bib50) 2002; 22 Zhang (10.1016/j.niox.2009.07.006_bib65) 2001; 15 Pollock (10.1016/j.niox.2009.07.006_bib3) 2001; 129 Abd-El-Aleem (10.1016/j.niox.2009.07.006_bib13) 2000; 191 Schaffer (10.1016/j.niox.2009.07.006_bib38) 1996; 63 Corraliza (10.1016/j.niox.2009.07.006_bib15) 2002; 29 Bronte (10.1016/j.niox.2009.07.006_bib46) 2005; 5 Noiri (10.1016/j.niox.2009.07.006_bib58) 1998; 274 Canturk (10.1016/j.niox.2009.07.006_bib51) 2001; 8 Chang (10.1016/j.niox.2009.07.006_bib64) 1998; 274 Albina (10.1016/j.niox.2009.07.006_bib34) 1988; 254 Frank (10.1016/j.niox.2009.07.006_bib62) 1998; 111 Witte (10.1016/j.niox.2009.07.006_bib78) 2003; 7 Albina (10.1016/j.niox.2009.07.006_bib20) 1993; 55 Giovannoni (10.1016/j.niox.2009.07.006_bib30) 1997; 34 Curran (10.1016/j.niox.2009.07.006_bib1) 2006; 14 Mori (10.1016/j.niox.2009.07.006_bib28) 2007; 137 Nirgiotis (10.1016/j.niox.2009.07.006_bib8) 1991; 26 Kirk (10.1016/j.niox.2009.07.006_bib10) 1993; 114 Markert (10.1016/j.niox.2009.07.006_bib43) 1994; 199 Moncada (10.1016/j.niox.2009.07.006_bib49) 1991; 43 Most (10.1016/j.niox.2009.07.006_bib60) 2002; 132 Barbul (10.1016/j.niox.2009.07.006_bib9) 1990; 108 Holan (10.1016/j.niox.2009.07.006_bib67) 2006; 81 Durante (10.1016/j.niox.2009.07.006_bib66) 2007; 34 Shashidharan (10.1016/j.niox.2009.07.006_bib11) 1999; 42 Seifter (10.1016/j.niox.2009.07.006_bib36) 1978; 84 Wright (10.1016/j.niox.2009.07.006_bib42) 1989; 160 Kepka-Lenhart (10.1016/j.niox.2009.07.006_bib75) 2000; 279 Munder (10.1016/j.niox.2009.07.006_bib69) 2006; 108 Albina (10.1016/j.niox.2009.07.006_bib14) 1990; 144 Barbul (10.1016/j.niox.2009.07.006_bib63) 2008; 138 Tsuei (10.1016/j.niox.2009.07.006_bib71) 2001; 51 Lesiewicz (10.1016/j.niox.2009.07.006_bib22) 1980; 116 Shimizu (10.1016/j.niox.2009.07.006_bib61) 1997; 24 Efron (10.1016/j.niox.2009.07.006_bib37) 2001; 98 Schaffer (10.1016/j.niox.2009.07.006_bib52) 1999; 165 Schaffer (10.1016/j.niox.2009.07.006_bib4) 1997; 71 Bruins (10.1016/j.niox.2009.07.006_bib6) 2002; 30 Reichner (10.1016/j.niox.2009.07.006_bib47) 1999; 154 Zunic (10.1016/j.niox.2009.07.006_bib39) 2009; 20 Maeno (10.1016/j.niox.2009.07.006_bib23) 1990; 46 Kapoor (10.1016/j.niox.2009.07.006_bib56) 2004; 165 Nolan (10.1016/j.niox.2009.07.006_bib45) 2007 Morris (10.1016/j.niox.2009.07.006_bib18) 1992; 12 Thornton (10.1016/j.niox.2009.07.006_bib53) 1998; 246 Williams (10.1016/j.niox.2009.07.006_bib33) 2002; 236 Norris (10.1016/j.niox.2009.07.006_bib5) 1995; 63 Lee (10.1016/j.niox.2009.07.006_bib35) 2001; 101 Gotoh (10.1016/j.niox.2009.07.006_bib77) 1999; 144 Xu (10.1016/j.niox.2009.07.006_bib79) 2004; 18 Rotondo (10.1016/j.niox.2009.07.006_bib70) 2009; 1 Ochoa (10.1016/j.niox.2009.07.006_bib72) 2001; 233 Shi (10.1016/j.niox.2009.07.006_bib54) 2001; 130 Witte (10.1016/j.niox.2009.07.006_bib2) 2002; 183 |
References_xml | – volume: 98 start-page: 2604 year: 2001 end-page: 2609 ident: bib57 article-title: Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Fukumura – volume: 184 start-page: 37 year: 1997 end-page: 43 ident: bib7 article-title: Acute protein-calorie malnutrition impairs wound healing: a possible role of decreased wound nitric oxide synthesis publication-title: J. Coll. Surg. contributor: fullname: Schaffer – volume: 42 start-page: 748 year: 1999 end-page: 757 ident: bib16 article-title: The role of nitric oxide synthase isoforms, arginase in the pathogenesis of diabetic foot ulcers: possible modulatory effects by transforming growth factor beta 1 publication-title: Diabetologia contributor: fullname: Jude – volume: 34 start-page: 906 year: 2007 end-page: 911 ident: bib66 article-title: Arginase: a critical regulator of nitric oxide synthesis and vascular function publication-title: Clin. Exp. Pharmacol. Physiol. contributor: fullname: Johnson – volume: 101 start-page: 104 year: 2001 end-page: 108 ident: bib35 article-title: Nitric oxide in the healing wound: a time-course study publication-title: J. Surg. Res. contributor: fullname: Lee – volume: 63 start-page: 2793 year: 1995 end-page: 2796 ident: bib5 article-title: Enhancement of macrophage microbicidal activity: supplemental arginine and citrulline augment nitric oxide production in murine peritoneal macrophages and promote intracellular killing of publication-title: Infect. Immun. contributor: fullname: Norris – volume: 108 start-page: 331 year: 1990 end-page: 336 ident: bib9 article-title: Arginine enhances wound healing and lymphocyte immune responses in humans publication-title: Surgery contributor: fullname: Barbul – volume: 34 start-page: 1080 year: 2002 end-page: 1090 ident: bib48 article-title: Enhanced utilization and altered metabolism of arginine in inflammatory macrophages caused by raised nitric oxide synthesis publication-title: Int. J. Biochem. Cell Biol. contributor: fullname: Hrabak – volume: 275 start-page: E740 year: 1998 end-page: E747 ident: bib76 article-title: Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells publication-title: Am. J. Physiol. contributor: fullname: Chen – volume: 144 start-page: 3877 year: 1990 end-page: 3880 ident: bib14 article-title: Temporal expression of different pathways of publication-title: J. Immunol. contributor: fullname: Albina – volume: 106 start-page: 419 year: 1996 end-page: 427 ident: bib55 article-title: Human dermal fibroblasts produce nitric oxide and express both constitutive and inducible nitric oxide synthase isoforms publication-title: J. Invest. Dermatol. contributor: fullname: Wang – volume: 81 start-page: 1708 year: 2006 end-page: 1715 ident: bib67 article-title: Production of nitric oxide during graft rejection is regulated by the Th1/Th2 balance, the arginase activity, and publication-title: Transplantation contributor: fullname: Holan – volume: 34 start-page: 193 year: 1997 end-page: 198 ident: bib30 article-title: Adaptation of the nitrate reductase and Griess reaction methods for the measurement of serum nitrate plus nitrite levels publication-title: Ann. Clin. Biochem. contributor: fullname: Giovannoni – volume: 165 start-page: 299 year: 2004 end-page: 307 ident: bib56 article-title: Effects of epicatechin gallate on wound healing and scar formation in a full thickness incisional wound healing model in rats publication-title: Am. J. Pathol. contributor: fullname: Kapoor – volume: 160 start-page: 813 year: 1989 end-page: 819 ident: bib42 article-title: Generation of nitric oxide by human neutrophils publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Wright – volume: 63 start-page: 237 year: 1996 end-page: 240 ident: bib38 article-title: Nitric oxide regulates wound healing publication-title: J. Surg. Res. contributor: fullname: Schaffer – volume: 24 start-page: 80 year: 1997 end-page: 87 ident: bib61 article-title: Immunohistochemical localization of nitric oxide synthase in normal human skin: expression of endothelial-type and inducible-type nitric oxide synthase in keratinocytes publication-title: J. Dermatol. contributor: fullname: Shimizu – volume: 15 start-page: 44 year: 2002 end-page: 54 ident: bib81 article-title: The influence of publication-title: Skin Pharmacol. Appl. Skin Physiol. contributor: fullname: Marsch – volume: 274 start-page: H342 year: 1998 end-page: H348 ident: bib64 article-title: Arginase modulates nitric oxide production in activated macrophages publication-title: Am. J. Physiol. contributor: fullname: Kuo – volume: 6 start-page: 223 year: 2003 end-page: 228 ident: bib26 article-title: Arginine availability, arginase, and the immune response publication-title: Curr. Opin. Clin. Nutr. Metab. Care contributor: fullname: Ochoa – volume: 183 start-page: 406 year: 2002 end-page: 412 ident: bib2 article-title: Role of nitric oxide in wound repair publication-title: Am. J. Surg. contributor: fullname: Barbul – volume: 46 start-page: 255 year: 1990 end-page: 268 ident: bib23 article-title: A study on the vital reaction in wounded skin: simultaneous determination of histamine and polyamines in injured rat skin by high-performance liquid chromatography publication-title: Forensic Sci. Int. contributor: fullname: Maeno – volume: 108 start-page: 1627 year: 2006 end-page: 1634 ident: bib69 article-title: Suppression of T-cell functions by human granulocyte arginase publication-title: Blood contributor: fullname: Munder – volume: 116 start-page: 1225 year: 1980 end-page: 1226 ident: bib22 article-title: Inhibition of rat skin ornithine decarboxylase by nitrofurazone publication-title: Arch. Dermatol. contributor: fullname: Goldsmith – volume: 105 start-page: 35 year: 2002 end-page: 42 ident: bib25 article-title: Upregulation of arginase expression in wound-derived fibroblasts publication-title: J. Surg. Res. contributor: fullname: Witte – volume: 24 start-page: 302 year: 2003 end-page: 306 ident: bib27 article-title: publication-title: Trends Immunol. contributor: fullname: Bronte – volume: 30 start-page: 417 year: 2009 end-page: 426 ident: bib29 article-title: Oral arginine supplementation and the effect on skin graft donor sites: a randomized clinical pilot study publication-title: J. Burn Care Res. contributor: fullname: Debats – volume: 67 start-page: 2493 year: 2000 end-page: 2512 ident: bib12 article-title: Early effects of exogenous arginine after the implantation of prosthetic material into the rat abdominal wall publication-title: Life Sci. contributor: fullname: Arbss – volume: 279 start-page: R2237 year: 2000 end-page: R2242 ident: bib75 article-title: Arginase I: a limiting factor for nitric oxide and polyamine synthesis by activated macrophages? publication-title: Am. J .Physiol. Regul. Integr. Comp. Physiol. contributor: fullname: Kepka-Lenhart – volume: 336 start-page: 1 year: 1998 end-page: 17 ident: bib24 article-title: Arginine metabolism: nitric oxide and beyond publication-title: Biochem. J. contributor: fullname: Morris – volume: 34 start-page: 455 year: 2001 end-page: 461 ident: bib32 article-title: A useful ELISA system for human liver-type arginase, and its utility in diagnosis of liver diseases publication-title: Clin. Biochem. contributor: fullname: Ikemoto – volume: 37 start-page: 515 year: 2004 end-page: 523 ident: bib80 article-title: Arginase pathway in human endothelial cells in pathophysiological conditions publication-title: J. Mol. Cell. Cardiol. contributor: fullname: Bachetti – volume: 30 start-page: 508 year: 2002 end-page: 517 ident: bib6 article-title: publication-title: Crit. Care Med. contributor: fullname: Bruins – volume: 191 start-page: 434 year: 2000 end-page: 442 ident: bib13 article-title: Expression of nitric oxide synthase isoforms and arginase in normal human skin and chronic venous leg ulcers publication-title: J. Pathol. contributor: fullname: Abd-El-Aleem – volume: 43 start-page: 109 year: 1991 end-page: 142 ident: bib49 article-title: Nitric oxide: physiology, pathophysiology, and pharmacology publication-title: Pharmacol. Rev. contributor: fullname: Higgs – volume: 71 start-page: 25 year: 1997 end-page: 31 ident: bib4 article-title: Nitric oxide metabolism in wounds publication-title: J. Surg. Res. contributor: fullname: Schaffer – volume: 246 start-page: 654 year: 1998 end-page: 659 ident: bib53 article-title: Enhanced collagen accumulation following direct transfection of the inducible nitric oxide synthase gene in cutaneous wounds publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Thornton – volume: 26 start-page: 936 year: 1991 end-page: 941 ident: bib8 article-title: The effects of an arginine-free enteral diet on wound healing and immune function in the postsurgical rat publication-title: J. Pediatr. Surg. contributor: fullname: Andrassy – volume: 129 start-page: 341 year: 2001 end-page: 350 ident: bib3 article-title: Nitric oxide synthase isoform expression in a porcine model of granulation tissue formation publication-title: Surgery contributor: fullname: Pollock – volume: 114 start-page: 155 year: 1993 end-page: 159 ident: bib10 article-title: Arginine stimulates wound healing and immune function in elderly human beings publication-title: Surgery contributor: fullname: Kirk – volume: 98 start-page: 16 year: 2001 end-page: 20 ident: bib37 article-title: A novel method of studying wound healing publication-title: J. Surg. Res. contributor: fullname: Efron – volume: 233 start-page: 393 year: 2001 end-page: 399 ident: bib72 article-title: Arginase I expression and activity in human mononuclear cells after injury publication-title: Ann. Surg. contributor: fullname: Ochoa – volume: 199 start-page: 1245 year: 1994 end-page: 1249 ident: bib43 article-title: Nitric oxide production by activated human neutrophils exposed to sodium azide and hydroxylamine: the role of oxygen radicals publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Mauel – volume: 49 start-page: 1005 year: 1980 end-page: 1061 ident: bib19 article-title: Metabolism of proline and the hydroxyprolines publication-title: Annu. Rev. Biochem. contributor: fullname: Frank – volume: 236 start-page: 369 year: 2002 end-page: 374 ident: bib33 article-title: Effect of a specialized amino acid mixture on human collagen deposition publication-title: Ann. Surg. contributor: fullname: Barbul – volume: 84 start-page: 224 year: 1978 end-page: 230 ident: bib36 article-title: Arginine: an essential amino acid for injured rats publication-title: Surgery contributor: fullname: Seifter – volume: 51 start-page: 497 year: 2001 end-page: 502 ident: bib71 article-title: Surgery induces human mononuclear cell arginase I expression publication-title: J. Trauma contributor: fullname: Tsuei – volume: 93 start-page: 567 year: 1994 end-page: 573 ident: bib21 article-title: Effect of putrescine on tissue transglutaminase activity in wounds: decreased breaking strength and increased matrix fucoprotein solubility publication-title: Plast. Reconstr. Surg. contributor: fullname: Bowness – volume: 137 start-page: 1616S year: 2007 end-page: 1620S ident: bib28 article-title: Regulation of nitric oxide synthesis and apoptosis by arginase and arginine recycling publication-title: J. Nutr. contributor: fullname: Mori – volume: 121 start-page: 1544 year: 2003 end-page: 1551 ident: bib17 article-title: Expression and activity of arginase isoenzymes during normal and diabetes-impaired skin repair publication-title: J. Invest. Dermatol. contributor: fullname: Frank – volume: 1 start-page: 1 year: 2009 end-page: 2 ident: bib70 article-title: IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer publication-title: Int. J. Cancer. contributor: fullname: Rotondo – volume: 7 start-page: 378 year: 2003 end-page: 385 ident: bib78 article-title: Arginase acts as an alternative pathway of publication-title: J. Gastrointest. Surg. contributor: fullname: Witte – volume: 130 start-page: 225 year: 2001 end-page: 229 ident: bib54 article-title: The role of iNOS in wound healing publication-title: Surgery contributor: fullname: Shi – volume: 53 start-page: 175 year: 2005 end-page: 179 ident: bib44 article-title: iNOS expression and NO production by neutrophils in cancer patients publication-title: Arch. Immunol. Ther. Exp. (Warsz) contributor: fullname: Jablonska – volume: 154 start-page: 1097 year: 1999 end-page: 1104 ident: bib47 article-title: Molecular and metabolic evidence for the restricted expression of inducible nitric oxide synthase in healing wounds publication-title: Am. J. Pathol. contributor: fullname: Reichner – volume: 274 start-page: C236 year: 1998 end-page: C244 ident: bib58 article-title: Podokinesis in endothelial cell migration: role of nitric oxide publication-title: Am. J. Physiol. contributor: fullname: Noiri – volume: 55 start-page: 97 year: 1993 end-page: 102 ident: bib20 article-title: Role of ornithine as a proline precursor in healing wounds publication-title: J. Surg. Res. contributor: fullname: Mastrofrancesco – volume: 254 start-page: E459 year: 1988 end-page: E467 ident: bib34 article-title: Arginine metabolism in wounds publication-title: Am. J. Physiol. contributor: fullname: Albina – volume: 15 start-page: 395 year: 2006 end-page: 399 ident: bib40 article-title: The effects of topical treatment with acidified nitrite on wound healing in normal and diabetic mice publication-title: Nitric Oxide contributor: fullname: Finnen – volume: 18 start-page: 1746 year: 2004 end-page: 1748 ident: bib79 article-title: Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension publication-title: FASEB J. contributor: fullname: Xu – volume: 162 start-page: 203 year: 2003 end-page: 211 ident: bib68 article-title: Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation publication-title: Am. J. Pathol. contributor: fullname: Bruch-Gerharz – volume: 109 start-page: 3084 year: 2007 end-page: 3087 ident: bib74 article-title: Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils publication-title: Blood contributor: fullname: Jacobsen – volume: 14 start-page: 376 year: 2006 end-page: 386 ident: bib1 article-title: Biological fate and clinical implications of arginine metabolism in tissue healing publication-title: Wound Repair Regen. contributor: fullname: Bouchier-Hayes – volume: 29 start-page: 2261 year: 2002 end-page: 2265 ident: bib15 article-title: Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide publication-title: J. Rheumatol. contributor: fullname: Moncada – volume: 15 start-page: 1264 year: 2001 end-page: 1266 ident: bib65 article-title: Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function publication-title: FASEB J. contributor: fullname: Zhang – volume: 8 start-page: 311 year: 2001 end-page: 315 ident: bib51 article-title: The role of publication-title: Eur. J. Emerg. Med. contributor: fullname: Canturk – volume: 5 start-page: 641 year: 2005 end-page: 654 ident: bib46 article-title: Regulation of immune responses by publication-title: Nat. Rev. Immunol. contributor: fullname: Zanovello – volume: 13 start-page: 374 year: 1994 end-page: 380 ident: bib31 article-title: Influence of storage conditions on normal plasma amino-acid concentrations publication-title: Clin. Nutr. contributor: fullname: Soeters – volume: 20 start-page: 253 year: 2009 end-page: 258 ident: bib39 article-title: Increased nitric oxide formation followed by increased arginase activity induces relative lack of arginine at the wound site and alters whole nutritional status in rats almost within the early healing period publication-title: Nitric Oxide contributor: fullname: Zunic – volume: 165 start-page: 262 year: 1999 end-page: 267 ident: bib52 article-title: Inhibition of nitric oxide synthesis in wounds: pharmacology and effect on accumulation of collagen in wounds in mice publication-title: Eur. J. Surg. contributor: fullname: Schaffer – volume: 132 start-page: 866 year: 2002 end-page: 876 ident: bib60 article-title: Characterization of incisional wound healing in inducible nitric oxide synthase knockout mice publication-title: Surgery contributor: fullname: Most – volume: 111 start-page: 1058 year: 1998 end-page: 1064 ident: bib62 article-title: Induction of inducible nitric oxide synthase and its corresponding tetrahydrobiopterin-cofactor-synthesizing enzyme GTP-cyclohydrolase I during cutaneous wound repair publication-title: J. Invest. Dermatol. contributor: fullname: Frank – volume: 144 start-page: 427 year: 1999 end-page: 434 ident: bib77 article-title: Arginase II downregulates nitric oxide (NO) production and prevents NO-mediated apoptosis in murine macrophage-derived RAW 264.7 cells publication-title: J. Cell Biol. contributor: fullname: Mori – volume: 276 start-page: C1271 year: 1999 end-page: C1281 ident: bib59 article-title: Nitric oxide modulation of focal adhesions in endothelial cells publication-title: Am. J. Physiol. contributor: fullname: Goligorsky – volume: 149 start-page: 84 year: 2008 end-page: 93 ident: bib41 article-title: Nitric oxide donor improves healing if applied on inflammatory and proliferative phase publication-title: J. Surg. Res. contributor: fullname: Amadeu – volume: 42 start-page: 1613 year: 1999 end-page: 1617 ident: bib11 article-title: Influence of arginine dietary supplementation on healing colonic anastomosis in the rat publication-title: Dis. Colon Rectum contributor: fullname: Shashidharan – volume: 12 start-page: 81 year: 1992 end-page: 101 ident: bib18 article-title: Regulation of enzymes of urea and arginine synthesis publication-title: Annu. Rev. Nutr. contributor: fullname: Morris – volume: 280 start-page: E75 year: 2001 end-page: E82 ident: bib73 article-title: Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells publication-title: Am. J. Physiol. Endocrinol. Metab. contributor: fullname: Li – volume: 22 start-page: 39 year: 2002 end-page: 53 ident: bib50 article-title: Effects of arginine, publication-title: Amino Acids contributor: fullname: Muhling – year: 2007 ident: bib45 article-title: Nitric oxide regulates neutrophil migration through microparticle formation publication-title: Am. J. Pathol. contributor: fullname: Nolan – volume: 138 start-page: 2021S year: 2008 end-page: 2024S ident: bib63 article-title: Proline precursors to sustain Mammalian collagen synthesis publication-title: J. Nutr. contributor: fullname: Barbul – volume: 30 start-page: 508 issue: 3 year: 2002 ident: 10.1016/j.niox.2009.07.006_bib6 article-title: l-Arginine supplementation in hyperdynamic endotoxemic pigs: effect on nitric oxide synthesis by the different organs publication-title: Crit. Care Med. doi: 10.1097/00003246-200203000-00003 contributor: fullname: Bruins – volume: 29 start-page: 2261 issue: 11 year: 2002 ident: 10.1016/j.niox.2009.07.006_bib15 article-title: Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide publication-title: J. Rheumatol. contributor: fullname: Corraliza – volume: 160 start-page: 813 issue: 2 year: 1989 ident: 10.1016/j.niox.2009.07.006_bib42 article-title: Generation of nitric oxide by human neutrophils publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/0006-291X(89)92506-0 contributor: fullname: Wright – volume: 138 start-page: 2021S issue: 10 year: 2008 ident: 10.1016/j.niox.2009.07.006_bib63 article-title: Proline precursors to sustain Mammalian collagen synthesis publication-title: J. Nutr. doi: 10.1093/jn/138.10.2021S contributor: fullname: Barbul – volume: 34 start-page: 906 issue: 9 year: 2007 ident: 10.1016/j.niox.2009.07.006_bib66 article-title: Arginase: a critical regulator of nitric oxide synthesis and vascular function publication-title: Clin. Exp. Pharmacol. Physiol. doi: 10.1111/j.1440-1681.2007.04638.x contributor: fullname: Durante – volume: 30 start-page: 417 issue: 3 year: 2009 ident: 10.1016/j.niox.2009.07.006_bib29 article-title: Oral arginine supplementation and the effect on skin graft donor sites: a randomized clinical pilot study publication-title: J. Burn Care Res. doi: 10.1097/BCR.0b013e3181a28c15 contributor: fullname: Debats – volume: 14 start-page: 376 issue: 4 year: 2006 ident: 10.1016/j.niox.2009.07.006_bib1 article-title: Biological fate and clinical implications of arginine metabolism in tissue healing publication-title: Wound Repair Regen. doi: 10.1111/j.1743-6109.2006.00151.x contributor: fullname: Curran – volume: 274 start-page: H342 issue: 1 Pt. 2 year: 1998 ident: 10.1016/j.niox.2009.07.006_bib64 article-title: Arginase modulates nitric oxide production in activated macrophages publication-title: Am. J. Physiol. contributor: fullname: Chang – volume: 98 start-page: 16 issue: 1 year: 2001 ident: 10.1016/j.niox.2009.07.006_bib37 article-title: A novel method of studying wound healing publication-title: J. Surg. Res. doi: 10.1006/jsre.2001.6168 contributor: fullname: Efron – volume: 1 start-page: 1 year: 2009 ident: 10.1016/j.niox.2009.07.006_bib70 article-title: IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer publication-title: Int. J. Cancer. contributor: fullname: Rotondo – volume: 108 start-page: 331 issue: 2 year: 1990 ident: 10.1016/j.niox.2009.07.006_bib9 article-title: Arginine enhances wound healing and lymphocyte immune responses in humans publication-title: Surgery contributor: fullname: Barbul – volume: 154 start-page: 1097 issue: 4 year: 1999 ident: 10.1016/j.niox.2009.07.006_bib47 article-title: Molecular and metabolic evidence for the restricted expression of inducible nitric oxide synthase in healing wounds publication-title: Am. J. Pathol. doi: 10.1016/S0002-9440(10)65362-X contributor: fullname: Reichner – volume: 12 start-page: 81 year: 1992 ident: 10.1016/j.niox.2009.07.006_bib18 article-title: Regulation of enzymes of urea and arginine synthesis publication-title: Annu. Rev. Nutr. doi: 10.1146/annurev.nu.12.070192.000501 contributor: fullname: Morris – volume: 43 start-page: 109 issue: 2 year: 1991 ident: 10.1016/j.niox.2009.07.006_bib49 article-title: Nitric oxide: physiology, pathophysiology, and pharmacology publication-title: Pharmacol. Rev. contributor: fullname: Moncada – volume: 51 start-page: 497 issue: 3 year: 2001 ident: 10.1016/j.niox.2009.07.006_bib71 article-title: Surgery induces human mononuclear cell arginase I expression publication-title: J. Trauma doi: 10.1097/00005373-200109000-00012 contributor: fullname: Tsuei – volume: 18 start-page: 1746 issue: 14 year: 2004 ident: 10.1016/j.niox.2009.07.006_bib79 article-title: Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension publication-title: FASEB J. doi: 10.1096/fj.04-2317fje contributor: fullname: Xu – volume: 336 start-page: 1 issue: Pt. 1 year: 1998 ident: 10.1016/j.niox.2009.07.006_bib24 article-title: Arginine metabolism: nitric oxide and beyond publication-title: Biochem. J. doi: 10.1042/bj3360001 contributor: fullname: Wu – volume: 280 start-page: E75 issue: 1 year: 2001 ident: 10.1016/j.niox.2009.07.006_bib73 article-title: Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.2001.280.1.E75 contributor: fullname: Li – volume: 67 start-page: 2493 issue: 20 year: 2000 ident: 10.1016/j.niox.2009.07.006_bib12 article-title: Early effects of exogenous arginine after the implantation of prosthetic material into the rat abdominal wall publication-title: Life Sci. doi: 10.1016/S0024-3205(00)00836-5 contributor: fullname: Arbss – volume: 34 start-page: 193 issue: Pt. 2 year: 1997 ident: 10.1016/j.niox.2009.07.006_bib30 article-title: Adaptation of the nitrate reductase and Griess reaction methods for the measurement of serum nitrate plus nitrite levels publication-title: Ann. Clin. Biochem. doi: 10.1177/000456329703400212 contributor: fullname: Giovannoni – volume: 149 start-page: 84 issue: 1 year: 2008 ident: 10.1016/j.niox.2009.07.006_bib41 article-title: Nitric oxide donor improves healing if applied on inflammatory and proliferative phase publication-title: J. Surg. Res. doi: 10.1016/j.jss.2007.10.015 contributor: fullname: Amadeu – volume: 53 start-page: 175 issue: 2 year: 2005 ident: 10.1016/j.niox.2009.07.006_bib44 article-title: iNOS expression and NO production by neutrophils in cancer patients publication-title: Arch. Immunol. Ther. Exp. (Warsz) contributor: fullname: Jablonska – volume: 165 start-page: 262 issue: 3 year: 1999 ident: 10.1016/j.niox.2009.07.006_bib52 article-title: Inhibition of nitric oxide synthesis in wounds: pharmacology and effect on accumulation of collagen in wounds in mice publication-title: Eur. J. Surg. doi: 10.1080/110241599750007153 contributor: fullname: Schaffer – volume: 84 start-page: 224 issue: 2 year: 1978 ident: 10.1016/j.niox.2009.07.006_bib36 article-title: Arginine: an essential amino acid for injured rats publication-title: Surgery contributor: fullname: Seifter – volume: 105 start-page: 35 issue: 1 year: 2002 ident: 10.1016/j.niox.2009.07.006_bib25 article-title: Upregulation of arginase expression in wound-derived fibroblasts publication-title: J. Surg. Res. doi: 10.1006/jsre.2002.6443 contributor: fullname: Witte – volume: 144 start-page: 427 issue: 3 year: 1999 ident: 10.1016/j.niox.2009.07.006_bib77 article-title: Arginase II downregulates nitric oxide (NO) production and prevents NO-mediated apoptosis in murine macrophage-derived RAW 264.7 cells publication-title: J. Cell Biol. doi: 10.1083/jcb.144.3.427 contributor: fullname: Gotoh – volume: 236 start-page: 369 issue: 3 year: 2002 ident: 10.1016/j.niox.2009.07.006_bib33 article-title: Effect of a specialized amino acid mixture on human collagen deposition publication-title: Ann. Surg. doi: 10.1097/00000658-200209000-00013 contributor: fullname: Williams – volume: 34 start-page: 1080 issue: 9 year: 2002 ident: 10.1016/j.niox.2009.07.006_bib48 article-title: Enhanced utilization and altered metabolism of arginine in inflammatory macrophages caused by raised nitric oxide synthesis publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/S1357-2725(02)00028-6 contributor: fullname: Mullner – volume: 137 start-page: 1616S issue: 6 Suppl. 2 year: 2007 ident: 10.1016/j.niox.2009.07.006_bib28 article-title: Regulation of nitric oxide synthesis and apoptosis by arginase and arginine recycling publication-title: J. Nutr. doi: 10.1093/jn/137.6.1616S contributor: fullname: Mori – volume: 101 start-page: 104 issue: 1 year: 2001 ident: 10.1016/j.niox.2009.07.006_bib35 article-title: Nitric oxide in the healing wound: a time-course study publication-title: J. Surg. Res. doi: 10.1006/jsre.2001.6261 contributor: fullname: Lee – volume: 5 start-page: 641 issue: 8 year: 2005 ident: 10.1016/j.niox.2009.07.006_bib46 article-title: Regulation of immune responses by l-arginine metabolism publication-title: Nat. Rev. Immunol. doi: 10.1038/nri1668 contributor: fullname: Bronte – volume: 15 start-page: 1264 issue: 7 year: 2001 ident: 10.1016/j.niox.2009.07.006_bib65 article-title: Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function publication-title: FASEB J. doi: 10.1096/fj.00-0681fje contributor: fullname: Zhang – volume: 22 start-page: 39 issue: 1 year: 2002 ident: 10.1016/j.niox.2009.07.006_bib50 article-title: Effects of arginine, l-alanyl-l-glutamine or taurine on neutrophil (PMN) free amino acid profiles and immune functions in vitro publication-title: Amino Acids doi: 10.1007/s726-002-8200-9 contributor: fullname: Muhling – volume: 274 start-page: C236 issue: 1 Pt. 1 year: 1998 ident: 10.1016/j.niox.2009.07.006_bib58 article-title: Podokinesis in endothelial cell migration: role of nitric oxide publication-title: Am. J. Physiol. doi: 10.1152/ajpcell.1998.274.1.C236 contributor: fullname: Noiri – volume: 46 start-page: 255 issue: 3 year: 1990 ident: 10.1016/j.niox.2009.07.006_bib23 article-title: A study on the vital reaction in wounded skin: simultaneous determination of histamine and polyamines in injured rat skin by high-performance liquid chromatography publication-title: Forensic Sci. Int. doi: 10.1016/0379-0738(90)90311-L contributor: fullname: Maeno – volume: 24 start-page: 302 issue: 6 year: 2003 ident: 10.1016/j.niox.2009.07.006_bib27 article-title: l-Arginine metabolism in myeloid cells controls T-lymphocyte functions publication-title: Trends Immunol. doi: 10.1016/S1471-4906(03)00132-7 contributor: fullname: Bronte – volume: 165 start-page: 299 issue: 1 year: 2004 ident: 10.1016/j.niox.2009.07.006_bib56 article-title: Effects of epicatechin gallate on wound healing and scar formation in a full thickness incisional wound healing model in rats publication-title: Am. J. Pathol. doi: 10.1016/S0002-9440(10)63297-X contributor: fullname: Kapoor – volume: 183 start-page: 406 issue: 4 year: 2002 ident: 10.1016/j.niox.2009.07.006_bib2 article-title: Role of nitric oxide in wound repair publication-title: Am. J. Surg. doi: 10.1016/S0002-9610(02)00815-2 contributor: fullname: Witte – volume: 71 start-page: 25 issue: 1 year: 1997 ident: 10.1016/j.niox.2009.07.006_bib4 article-title: Nitric oxide metabolism in wounds publication-title: J. Surg. Res. doi: 10.1006/jsre.1997.5137 contributor: fullname: Schaffer – volume: 15 start-page: 395 issue: 4 year: 2006 ident: 10.1016/j.niox.2009.07.006_bib40 article-title: The effects of topical treatment with acidified nitrite on wound healing in normal and diabetic mice publication-title: Nitric Oxide doi: 10.1016/j.niox.2006.04.002 contributor: fullname: Weller – volume: 121 start-page: 1544 issue: 6 year: 2003 ident: 10.1016/j.niox.2009.07.006_bib17 article-title: Expression and activity of arginase isoenzymes during normal and diabetes-impaired skin repair publication-title: J. Invest. Dermatol. doi: 10.1046/j.1523-1747.2003.12610.x contributor: fullname: Kampfer – volume: 81 start-page: 1708 issue: 12 year: 2006 ident: 10.1016/j.niox.2009.07.006_bib67 article-title: Production of nitric oxide during graft rejection is regulated by the Th1/Th2 balance, the arginase activity, and l-arginine metabolism publication-title: Transplantation doi: 10.1097/01.tp.0000226067.89690.2b contributor: fullname: Holan – volume: 34 start-page: 455 issue: 6 year: 2001 ident: 10.1016/j.niox.2009.07.006_bib32 article-title: A useful ELISA system for human liver-type arginase, and its utility in diagnosis of liver diseases publication-title: Clin. Biochem. doi: 10.1016/S0009-9120(01)00254-5 contributor: fullname: Ikemoto – volume: 111 start-page: 1058 issue: 6 year: 1998 ident: 10.1016/j.niox.2009.07.006_bib62 article-title: Induction of inducible nitric oxide synthase and its corresponding tetrahydrobiopterin-cofactor-synthesizing enzyme GTP-cyclohydrolase I during cutaneous wound repair publication-title: J. Invest. Dermatol. doi: 10.1046/j.1523-1747.1998.00434.x contributor: fullname: Frank – volume: 233 start-page: 393 issue: 3 year: 2001 ident: 10.1016/j.niox.2009.07.006_bib72 article-title: Arginase I expression and activity in human mononuclear cells after injury publication-title: Ann. Surg. doi: 10.1097/00000658-200103000-00014 contributor: fullname: Ochoa – volume: 275 start-page: E740 issue: 5 Pt. 1 year: 1998 ident: 10.1016/j.niox.2009.07.006_bib76 article-title: Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells publication-title: Am. J. Physiol. contributor: fullname: Morris – volume: 162 start-page: 203 issue: 1 year: 2003 ident: 10.1016/j.niox.2009.07.006_bib68 article-title: Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation publication-title: Am. J. Pathol. doi: 10.1016/S0002-9440(10)63811-4 contributor: fullname: Bruch-Gerharz – volume: 254 start-page: E459 issue: 4 Pt. 1 year: 1988 ident: 10.1016/j.niox.2009.07.006_bib34 article-title: Arginine metabolism in wounds publication-title: Am. J. Physiol. contributor: fullname: Albina – volume: 49 start-page: 1005 year: 1980 ident: 10.1016/j.niox.2009.07.006_bib19 article-title: Metabolism of proline and the hydroxyprolines publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.bi.49.070180.005041 contributor: fullname: Adams – volume: 13 start-page: 374 year: 1994 ident: 10.1016/j.niox.2009.07.006_bib31 article-title: Influence of storage conditions on normal plasma amino-acid concentrations publication-title: Clin. Nutr. doi: 10.1016/0261-5614(94)90028-0 contributor: fullname: van Eijk – volume: 130 start-page: 225 issue: 2 year: 2001 ident: 10.1016/j.niox.2009.07.006_bib54 article-title: The role of iNOS in wound healing publication-title: Surgery doi: 10.1067/msy.2001.115837 contributor: fullname: Shi – volume: 132 start-page: 866 issue: 5 year: 2002 ident: 10.1016/j.niox.2009.07.006_bib60 article-title: Characterization of incisional wound healing in inducible nitric oxide synthase knockout mice publication-title: Surgery doi: 10.1067/msy.2002.127422 contributor: fullname: Most – volume: 42 start-page: 748 issue: 6 year: 1999 ident: 10.1016/j.niox.2009.07.006_bib16 article-title: The role of nitric oxide synthase isoforms, arginase in the pathogenesis of diabetic foot ulcers: possible modulatory effects by transforming growth factor beta 1 publication-title: Diabetologia doi: 10.1007/s001250051224 contributor: fullname: Jude – volume: 7 start-page: 378 issue: 3 year: 2003 ident: 10.1016/j.niox.2009.07.006_bib78 article-title: Arginase acts as an alternative pathway of l-arginine metabolism in experimental colon anastomosis publication-title: J. Gastrointest. Surg. doi: 10.1016/S1091-255X(02)00431-6 contributor: fullname: Witte – volume: 20 start-page: 253 issue: 4 year: 2009 ident: 10.1016/j.niox.2009.07.006_bib39 article-title: Increased nitric oxide formation followed by increased arginase activity induces relative lack of arginine at the wound site and alters whole nutritional status in rats almost within the early healing period publication-title: Nitric Oxide doi: 10.1016/j.niox.2009.01.005 contributor: fullname: Zunic – volume: 98 start-page: 2604 issue: 5 year: 2001 ident: 10.1016/j.niox.2009.07.006_bib57 article-title: Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.041359198 contributor: fullname: Fukumura – volume: 116 start-page: 1225 issue: 11 year: 1980 ident: 10.1016/j.niox.2009.07.006_bib22 article-title: Inhibition of rat skin ornithine decarboxylase by nitrofurazone publication-title: Arch. Dermatol. doi: 10.1001/archderm.116.11.1225 contributor: fullname: Lesiewicz – volume: 191 start-page: 434 issue: 4 year: 2000 ident: 10.1016/j.niox.2009.07.006_bib13 article-title: Expression of nitric oxide synthase isoforms and arginase in normal human skin and chronic venous leg ulcers publication-title: J. Pathol. doi: 10.1002/1096-9896(2000)9999:9999<::AID-PATH654>3.0.CO;2-S contributor: fullname: Abd-El-Aleem – volume: 246 start-page: 654 issue: 3 year: 1998 ident: 10.1016/j.niox.2009.07.006_bib53 article-title: Enhanced collagen accumulation following direct transfection of the inducible nitric oxide synthase gene in cutaneous wounds publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1998.8681 contributor: fullname: Thornton – year: 2007 ident: 10.1016/j.niox.2009.07.006_bib45 article-title: Nitric oxide regulates neutrophil migration through microparticle formation publication-title: Am. J. Pathol. contributor: fullname: Nolan – volume: 24 start-page: 80 issue: 2 year: 1997 ident: 10.1016/j.niox.2009.07.006_bib61 article-title: Immunohistochemical localization of nitric oxide synthase in normal human skin: expression of endothelial-type and inducible-type nitric oxide synthase in keratinocytes publication-title: J. Dermatol. doi: 10.1111/j.1346-8138.1997.tb02748.x contributor: fullname: Shimizu – volume: 8 start-page: 311 issue: 4 year: 2001 ident: 10.1016/j.niox.2009.07.006_bib51 article-title: The role of l-arginine and neutrophils on incisional wound healing publication-title: Eur. J. Emerg. Med. doi: 10.1097/00063110-200112000-00012 contributor: fullname: Canturk – volume: 37 start-page: 515 issue: 2 year: 2004 ident: 10.1016/j.niox.2009.07.006_bib80 article-title: Arginase pathway in human endothelial cells in pathophysiological conditions publication-title: J. Mol. Cell. Cardiol. doi: 10.1016/j.yjmcc.2004.05.004 contributor: fullname: Bachetti – volume: 42 start-page: 1613 issue: 12 year: 1999 ident: 10.1016/j.niox.2009.07.006_bib11 article-title: Influence of arginine dietary supplementation on healing colonic anastomosis in the rat publication-title: Dis. Colon Rectum doi: 10.1007/BF02236217 contributor: fullname: Shashidharan – volume: 26 start-page: 936 issue: 8 year: 1991 ident: 10.1016/j.niox.2009.07.006_bib8 article-title: The effects of an arginine-free enteral diet on wound healing and immune function in the postsurgical rat publication-title: J. Pediatr. Surg. doi: 10.1016/0022-3468(91)90840-P contributor: fullname: Nirgiotis – volume: 63 start-page: 2793 issue: 7 year: 1995 ident: 10.1016/j.niox.2009.07.006_bib5 article-title: Enhancement of macrophage microbicidal activity: supplemental arginine and citrulline augment nitric oxide production in murine peritoneal macrophages and promote intracellular killing of Trypanosoma cruzi publication-title: Infect. Immun. doi: 10.1128/IAI.63.7.2793-2796.1995 contributor: fullname: Norris – volume: 6 start-page: 223 issue: 2 year: 2003 ident: 10.1016/j.niox.2009.07.006_bib26 article-title: Arginine availability, arginase, and the immune response publication-title: Curr. Opin. Clin. Nutr. Metab. Care doi: 10.1097/00075197-200303000-00012 contributor: fullname: Bansal – volume: 108 start-page: 1627 issue: 5 year: 2006 ident: 10.1016/j.niox.2009.07.006_bib69 article-title: Suppression of T-cell functions by human granulocyte arginase publication-title: Blood doi: 10.1182/blood-2006-11-010389 contributor: fullname: Munder – volume: 63 start-page: 237 issue: 1 year: 1996 ident: 10.1016/j.niox.2009.07.006_bib38 article-title: Nitric oxide regulates wound healing publication-title: J. Surg. Res. doi: 10.1006/jsre.1996.0254 contributor: fullname: Schaffer – volume: 199 start-page: 1245 issue: 3 year: 1994 ident: 10.1016/j.niox.2009.07.006_bib43 article-title: Nitric oxide production by activated human neutrophils exposed to sodium azide and hydroxylamine: the role of oxygen radicals publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1994.1364 contributor: fullname: Markert – volume: 129 start-page: 341 issue: 3 year: 2001 ident: 10.1016/j.niox.2009.07.006_bib3 article-title: Nitric oxide synthase isoform expression in a porcine model of granulation tissue formation publication-title: Surgery doi: 10.1067/msy.2001.111700 contributor: fullname: Pollock – volume: 276 start-page: C1271 issue: 6 Pt. 1 year: 1999 ident: 10.1016/j.niox.2009.07.006_bib59 article-title: Nitric oxide modulation of focal adhesions in endothelial cells publication-title: Am. J. Physiol. doi: 10.1152/ajpcell.1999.276.6.C1271 contributor: fullname: Goligorsky – volume: 109 start-page: 3084 issue: 7 year: 2007 ident: 10.1016/j.niox.2009.07.006_bib74 article-title: Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils publication-title: Blood doi: 10.1182/blood-2006-06-032599 contributor: fullname: Jacobsen – volume: 184 start-page: 37 issue: 1 year: 1997 ident: 10.1016/j.niox.2009.07.006_bib7 article-title: Acute protein-calorie malnutrition impairs wound healing: a possible role of decreased wound nitric oxide synthesis publication-title: J. Coll. Surg. contributor: fullname: Schaffer – volume: 114 start-page: 155 issue: 2 year: 1993 ident: 10.1016/j.niox.2009.07.006_bib10 article-title: Arginine stimulates wound healing and immune function in elderly human beings publication-title: Surgery contributor: fullname: Kirk – volume: 15 start-page: 44 issue: 1 year: 2002 ident: 10.1016/j.niox.2009.07.006_bib81 article-title: The influence of l-arginine on the regulation of epidermal arginase publication-title: Skin Pharmacol. Appl. Skin Physiol. doi: 10.1159/000049388 contributor: fullname: Wohlrab – volume: 55 start-page: 97 issue: 1 year: 1993 ident: 10.1016/j.niox.2009.07.006_bib20 article-title: Role of ornithine as a proline precursor in healing wounds publication-title: J. Surg. Res. doi: 10.1006/jsre.1993.1114 contributor: fullname: Albina – volume: 106 start-page: 419 issue: 3 year: 1996 ident: 10.1016/j.niox.2009.07.006_bib55 article-title: Human dermal fibroblasts produce nitric oxide and express both constitutive and inducible nitric oxide synthase isoforms publication-title: J. Invest. Dermatol. doi: 10.1111/1523-1747.ep12343428 contributor: fullname: Wang – volume: 279 start-page: R2237 issue: 6 year: 2000 ident: 10.1016/j.niox.2009.07.006_bib75 article-title: Arginase I: a limiting factor for nitric oxide and polyamine synthesis by activated macrophages? publication-title: Am. J .Physiol. Regul. Integr. Comp. Physiol. doi: 10.1152/ajpregu.2000.279.6.R2237 contributor: fullname: Kepka-Lenhart – volume: 144 start-page: 3877 issue: 10 year: 1990 ident: 10.1016/j.niox.2009.07.006_bib14 article-title: Temporal expression of different pathways of l-arginine metabolism in healing wounds publication-title: J. Immunol. doi: 10.4049/jimmunol.144.10.3877 contributor: fullname: Albina – volume: 93 start-page: 567 issue: 3 year: 1994 ident: 10.1016/j.niox.2009.07.006_bib21 article-title: Effect of putrescine on tissue transglutaminase activity in wounds: decreased breaking strength and increased matrix fucoprotein solubility publication-title: Plast. Reconstr. Surg. doi: 10.1097/00006534-199493030-00020 contributor: fullname: Dolynchuk |
SSID | ssj0004386 |
Score | 2.2518063 |
Snippet | Arginine supplementation has been identified as advantageous in experimental wound healing. However, the mechanisms underlying this beneficial effect in tissue... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 175 |
SubjectTerms | Acute wounds Adult Aged Arginase Arginase - analysis Arginase - metabolism Arginine Arginine - administration & dosage Arginine - metabolism Citrulline - blood Dietary Supplements Female Human Humans Male Middle Aged Nitrates - blood Nitric oxide Nitric Oxide Synthase Type II - metabolism Nitric Oxide Synthase Type III - metabolism Nitrites - blood NOS Ornithine - blood Prospective Studies Skin - cytology Skin - injuries Skin - metabolism Skin Transplantation Wound healing Wound Healing - drug effects |
Title | Role of arginine in superficial wound healing in man |
URI | https://dx.doi.org/10.1016/j.niox.2009.07.006 https://www.ncbi.nlm.nih.gov/pubmed/19638312 https://search.proquest.com/docview/733615179 |
Volume | 21 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JTsMwEB1VRQguCFqWslQ-IC4otNmc5FgqqrJVqFCpt8h2HBREk6qLgAvfjsdJVHEoB06JEjuxxtb4jWd5AOdxHESCMWHE0qKGo2w3A9MfDUYVOuemF8sIE4UfB7Q_cu7G7rgC3TIXBsMqC92f63StrYsnrUKarWmStJ7Nth_4FF0EaNjoHC4stqXW9NX3KszDsTXbIzY2sHWROJPHeKVJ9lnUrMRKhnTd5rQOfOpNqLcLOwV6JJ18gHtQkWkN6p1UWc6TL3JBdDynPiivweZ1ebfVLVnd6uAMs3dJspiw2StyQ0iSpGS-nCJZNZ6ekw_kWSKIH9Wmhi8nLN2HUe_mpds3CuYEQyj8sDAs6QrLVtDH45QrgGcp8TOPRT7CP1-YLrcpo7bFXYUWY972GPdELE1PMGVwuNI-gGqapfIICKcBZVz1jx3p0Ag_aNmUysinfiSEbMBlKbJwmhfICMvIsbcQBYxMl0HYRj83bYBbSjX8Nc2h0uB_9iPlFIRKYOjUYKnMlvMQyzmaWGesAYf51KyGgcrFNq3jf_70BLa170hnHp5CdTFbyjMFQRa8qddYEzY63eHDE15v7_uDH4Gi2s4 |
link.rule.ids | 315,783,787,4511,24130,27938,27939,45599,45693 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JTsMwEB1VrVC5IGhZyuoD4oKiNpuTHEtF1dLlAK3Um2U7DiqiSdVFwN_jySLEoRy4RUmcWDPW-I1neQC3URSEknNpRMqihqN9NwPLHw1ONToXphepEAuFR2PamzpPM3dWgk5RC4Nplbntz2x6aq3zO81cms3lfN58MVt-4FMMEaBjgzVcFY0GAr3YK-3-oDf-KY-0U8JHfN_AAXntTJbmFc-Tz7xtJTYzpLv2p134M92HuodwkANI0s7meAQlFdeg3o6187z4InckTelMz8prsPdQXFU7BbFbHZzn5F2RJCJ89Yr0EIrMY7LeLpGvGg_QyQdSLRGEkHpfw4cLHh_DtPs46fSMnDzBkBpCbAxLudKyNfrxBBUa41laA9zjoY8I0JemK2zKqW0JVwPGSLQ8LjwZKdOTXPscrrJPoBwnsToDImhAudDjI0c5NMQPWjalKvSpH0qpGnBfiIwtsx4ZrEgee2MoYCS7DFgLQ920AW4hVfZL00wb8T_HkUIFTAsM4xo8Vsl2zbCjo4mtxhpwmqnmZxpoX2zTOv_nT2-g2puMhmzYHw8uYD8NJaWFiJdQ3qy26kojko24zlfcN1Vn2_Y |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Role+of+arginine+in+superficial+wound+healing+in+man&rft.jtitle=Nitric+oxide&rft.au=Debats%2C+I+B+J+G&rft.au=Wolfs%2C+T+G+A+M&rft.au=Gotoh%2C+T&rft.au=Cleutjens%2C+J+P+M&rft.date=2009-11-01&rft.eissn=1089-8611&rft.volume=21&rft.issue=3-4&rft.spage=175&rft.epage=183&rft_id=info:doi/10.1016%2Fj.niox.2009.07.006&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1089-8603&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1089-8603&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1089-8603&client=summon |