Nuclear DNA fragmentation and morphological alterations in adult rabbit skeletal muscle after short-term immobilization

• Published in: Cell and tissue research Vol. 302; no. 2; pp. 235 - 241
• Main Authors: Smith, H K, Maxwell, L, Martyn, J A, Bass, J J
• Format: Journal Article
• Language: English
• Published: Germany 01.11.2000
• Subjects: Animals; Apoptosis; Cell Nucleus - ultrastructure; DNA Fragmentation; Immobilization; In Situ Nick-End Labeling; Microscopy, Electron; Mitochondria - ultrastructure; Muscle, Skeletal - physiology; Muscle, Skeletal - ultrastructure; Muscular Atrophy; Rabbits

Nuclear DNA fragmentation and ultrastructural changes, indicative of myonuclear apoptosis, were examined in adult skeletal muscle in response to short-term immobilization. Adult rabbits were allocated to 2 days (n=5) or 6 days (n=5) of unilateral casting of the ankle in full plantar flexion or were...