Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines

• Published in: Molecular cancer research Vol. 8; no. 10; pp. 1344 - 1357
• Main Authors: Bunt, Jens, de Haas, Talitha G, Hasselt, Nancy E, Zwijnenburg, Danny A, Koster, Jan, Versteeg, Rogier, Kool, Marcel
• Format: Journal Article
• Language: English
• Published: United States 01.10.2010
• Subjects: Cell Cycle - genetics; Cell Line, Tumor; Cell Proliferation; Cellular Senescence - genetics; Cerebellar Neoplasms - genetics; Cerebellar Neoplasms - metabolism; Cerebellar Neoplasms - pathology; Gene Expression Regulation, Neoplastic; Humans; Medulloblastoma - genetics; Medulloblastoma - metabolism; Medulloblastoma - pathology; Otx Transcription Factors - biosynthesis; Otx Transcription Factors - genetics

The transcription factor orthodenticle homeobox 2 (OTX2) has been implicated in the pathogenesis of medulloblastoma, as it is often highly expressed and sometimes amplified in these tumors. Little is known of the downstream pathways regulated by OTX2. We therefore generated MED8A and DAOY medullobla...