Dexamethasone causes less steroid-induced alkalemia than methylprednisolone or hydrocortisone

• Published in: Critical care medicine Vol. 12; no. 4; p. 384
• Main Authors: Chernow, B, Vernoski, B K, Zaloga, G P, Cook, D, D'Angona, Jr, D, Van Ness, M, Casey, L C, Fletcher, J R
• Format: Journal Article
• Language: English
• Published: United States 01.04.1984
• Subjects: Acid-Base Imbalance - chemically induced; Alkalosis - chemically induced; Animals; Dexamethasone - toxicity; Hydrocortisone - toxicity; Hydrogen-Ion Concentration; Male; Methylprednisolone - toxicity; Papio; Random Allocation

Corticosteroid-induced metabolic alkalemia is an important ICU problem because many of these patients may compensate by alveolar hypoventilation. The effects of 3 commonly used steroids on arterial pH, PaCO2, and serum bicarbonate concentrations were studied in 24 healthy male baboons randomly divid...