Medicinal chemistry advances in targeting class I histone deacetylases

• Published in: Exploration of targeted anti-tumor therapy Vol. 4; no. 4; pp. 757 - 779
• Main Authors: Abdallah, Diaaeldin I., de Araujo, Elvin D., Patel, Naman H., Hasan, Lina S., Moriggl, Richard, Krämer, Oliver H., Gunning, Patrick T.
• Format: Journal Article
• Language: English
• Published: Open Exploration Publishing 2023; Open Exploration Publishing Inc
• Subjects: cap group; epigenetic regulation; histone deacetylases; medicinal chemistry; Review; small-molecule inhibitors; zinc-binding group

Histone deacetylases (HDACs) are a class of zinc (Zn)-dependent metalloenzymes that are responsible for epigenetic modifications. HDACs are largely associated with histone proteins that regulate gene expression at the DNA level. This tight regulation is controlled by acetylation [via histone acetyl...