Risk assessment of variant Creutzfeldt-Jakob disease in corneal transplantation

While corneal transplantation is known to have a potential risk of transmission of variant Creutzfeldt-Jacob Disease (vCJD), the magnitude of this risk has not been quantified. A case report is presented of a 73 year-old man with a penetrating keratoplasty graft from corneal tissue that was recalled...

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Published inAmerican journal of ophthalmology case reports Vol. 30; p. 101856
Main Authors Desilets, Jeffrey, Mittal, Abhiniti, Sellick, John A., Patel, Sangita P.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2023
Elsevier
Subjects
Case Report
Corneal transplantation
Risk assessment
Variant Creutzfeldt-Jakob disease
Variant Creutzfeldt-Jakob disease
Risk assessment
Corneal transplantation
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Abstract While corneal transplantation is known to have a potential risk of transmission of variant Creutzfeldt-Jacob Disease (vCJD), the magnitude of this risk has not been quantified. A case report is presented of a 73 year-old man with a penetrating keratoplasty graft from corneal tissue that was recalled after transplantation due to risk of vCJD because it was later discovered that the donor had traveled to the United Kingdom (UK). Probabilities of vCJD transmission were extrapolated using Creutzfeldt-Jacob Disease (CJD) mortality (incidence) rate, all-cause death rate, and rate of recovery for intended transplantation. An overestimate of the risk of transplanting a cornea infected with vCJD in 2018 was 1 in 940,000. The true risk of vCJD transmission would be even lower due to an incomplete infectivity rate. We conclude that the risk of transmission of latent vCJD by corneal transplantation from a donor who traveled to the UK from 1980 to 1996 is exceedingly low.
AbstractList Purpose: While corneal transplantation is known to have a potential risk of transmission of variant Creutzfeldt-Jacob Disease (vCJD), the magnitude of this risk has not been quantified. Observations: A case report is presented of a 73 year-old man with a penetrating keratoplasty graft from corneal tissue that was recalled after transplantation due to risk of vCJD because it was later discovered that the donor had traveled to the United Kingdom (UK). Probabilities of vCJD transmission were extrapolated using Creutzfeldt-Jacob Disease (CJD) mortality (incidence) rate, all-cause death rate, and rate of recovery for intended transplantation. Conclusions: An overestimate of the risk of transplanting a cornea infected with vCJD in 2018 was 1 in 940,000. The true risk of vCJD transmission would be even lower due to an incomplete infectivity rate. We conclude that the risk of transmission of latent vCJD by corneal transplantation from a donor who traveled to the UK from 1980 to 1996 is exceedingly low.
While corneal transplantation is known to have a potential risk of transmission of variant Creutzfeldt-Jacob Disease (vCJD), the magnitude of this risk has not been quantified. A case report is presented of a 73 year-old man with a penetrating keratoplasty graft from corneal tissue that was recalled after transplantation due to risk of vCJD because it was later discovered that the donor had traveled to the United Kingdom (UK). Probabilities of vCJD transmission were extrapolated using Creutzfeldt-Jacob Disease (CJD) mortality (incidence) rate, all-cause death rate, and rate of recovery for intended transplantation. An overestimate of the risk of transplanting a cornea infected with vCJD in 2018 was 1 in 940,000. The true risk of vCJD transmission would be even lower due to an incomplete infectivity rate. We conclude that the risk of transmission of latent vCJD by corneal transplantation from a donor who traveled to the UK from 1980 to 1996 is exceedingly low.
ArticleNumber 101856
Author Sellick, John A.
Mittal, Abhiniti
Desilets, Jeffrey
Patel, Sangita P.
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10.1007/s40123-020-00272-8
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Keywords Variant Creutzfeldt-Jakob disease
Risk assessment
Corneal transplantation
Language English
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References (bib6) 2018
Beck, Kewell, Asenova (bib2) 2007; 38
Armitage, Tullo, Ironside (bib7) 2009; 23
(bib8) 2020
(bib3) 2014
Martheswaran, Desautels, Moshirfar (bib5) 2020; 9
Brandel, Vlaicu, Culeux (bib9) 2020; 383
Geschwind (bib1) 2015; 21
(bib10) Oct. 9, 2018
(bib4) 2019
Beck (10.1016/j.ajoc.2023.101856_bib2) 2007; 38
Brandel (10.1016/j.ajoc.2023.101856_bib9) 2020; 383
Martheswaran (10.1016/j.ajoc.2023.101856_bib5) 2020; 9
Armitage (10.1016/j.ajoc.2023.101856_bib7) 2009; 23
Geschwind (10.1016/j.ajoc.2023.101856_bib1) 2015; 21
References_xml – volume: 23
  start-page: 1926
  year: 2009
  end-page: 1930
  ident: bib7
  article-title: Risk of Creutzfeldt-Jakob disease transmission by ocular surgery and tissue transplantation
  publication-title: Eye
  contributor:
    fullname: Ironside
– volume: 21
  start-page: 1612
  year: 2015
  end-page: 1638
  ident: bib1
  article-title: Prion diseases
  publication-title: Continuum
  contributor:
    fullname: Geschwind
– volume: 9
  start-page: 465
  year: 2020
  end-page: 483
  ident: bib5
  article-title: A contemporary risk analysis of iatrogenic transmission of creutzfeldt-jakob disease (CJD) via corneal transplantation in the United States
  publication-title: Ophthalmol Ther
  contributor:
    fullname: Moshirfar
– year: 2019
  ident: bib4
  article-title: Eye Banking statistical report [Eye Bank association of American (EBAA)]. 2020
– year: 2020
  ident: bib8
  article-title: Creutzfeldt-jakob disease in the UK
– year: Oct. 9, 2018
  ident: bib10
  article-title: vCJD cases reported in the US [centers for disease control and prevention]
– year: 2018
  ident: bib6
  article-title: Creutzfeldt-jakob disease surveillance in the UK [the national CJD Research & surveillance unit]
– volume: 383
  start-page: 83
  year: 2020
  end-page: 85
  ident: bib9
  article-title: Variant creutzfeldt-jakob disease diagnosed 7.5 Years after occupational exposure
  publication-title: N Engl J Med
  contributor:
    fullname: Culeux
– year: 2014
  ident: bib3
  article-title: Donor greater than 12 Years old [American association of tissue banks]. September 10
– volume: 38
  year: 2007
  ident: bib2
  article-title: BSE crisis and food safety regulation: a comparison of the UK and Germany
  publication-title: The York Management School Working Papers
  contributor:
    fullname: Asenova
– volume: 383
  start-page: 83
  issue: 1
  year: 2020
  ident: 10.1016/j.ajoc.2023.101856_bib9
  article-title: Variant creutzfeldt-jakob disease diagnosed 7.5 Years after occupational exposure
  publication-title: N Engl J Med
  doi: 10.1056/NEJMc2000687
  contributor:
    fullname: Brandel
– volume: 9
  start-page: 465
  issue: 3
  year: 2020
  ident: 10.1016/j.ajoc.2023.101856_bib5
  article-title: A contemporary risk analysis of iatrogenic transmission of creutzfeldt-jakob disease (CJD) via corneal transplantation in the United States
  publication-title: Ophthalmol Ther
  doi: 10.1007/s40123-020-00272-8
  contributor:
    fullname: Martheswaran
– volume: 21
  start-page: 1612
  issue: 6 Neuroinfectious Disease
  year: 2015
  ident: 10.1016/j.ajoc.2023.101856_bib1
  article-title: Prion diseases
  publication-title: Continuum
  contributor:
    fullname: Geschwind
– volume: 23
  start-page: 1926
  issue: 10
  year: 2009
  ident: 10.1016/j.ajoc.2023.101856_bib7
  article-title: Risk of Creutzfeldt-Jakob disease transmission by ocular surgery and tissue transplantation
  publication-title: Eye
  doi: 10.1038/eye.2008.381
  contributor:
    fullname: Armitage
– volume: 38
  year: 2007
  ident: 10.1016/j.ajoc.2023.101856_bib2
  article-title: BSE crisis and food safety regulation: a comparison of the UK and Germany
  publication-title: The York Management School Working Papers
  contributor:
    fullname: Beck
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Purpose: While corneal transplantation is known to have a potential risk of transmission of variant Creutzfeldt-Jacob Disease (vCJD), the magnitude of this...
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SubjectTerms Case Report
Corneal transplantation
Risk assessment
Variant Creutzfeldt-Jakob disease
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Title Risk assessment of variant Creutzfeldt-Jakob disease in corneal transplantation
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