PET imaging of EGFR expression in nude mice bearing MDA-MB-468, a human breast adenocarcinoma

• Published in: Nuclear medicine communications Vol. 32; no. 7; p. 563
• Main Authors: Sadri, Kayvan, Ren, Qing, Zhang, Kaijun, Paudyal, Bishnuhari, Devadhas, Devakumar, Rodeck, Ulrich, Thakur, Mathew
• Format: Journal Article
• Language: English
• Published: England 01.07.2011
• Subjects: Adenocarcinoma - diagnostic imaging; Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Animals; Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - metabolism; Antibodies, Monoclonal - pharmacokinetics; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Line, Tumor; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Organometallic Compounds - chemistry; Organometallic Compounds - metabolism; Organometallic Compounds - pharmacokinetics; Positron-Emission Tomography - methods; Radiochemistry; Receptor, Epidermal Growth Factor - metabolism; Time Factors
• ISSN: 1473-5628
• DOI: 10.1097/MNM.0b013e3283419523

Cetuximab is a monoclonal antibody that binds to and inhibits the epidermal growth factor receptor (EGFR). EGFR overexpression has been observed in a subset of breast cancers. The purpose of this study was to evaluate 64Cu-labeled cetuximab as an imaging agent using MDA-MB-468 breast cancer cells. C...