Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions - Nasrin, Shamema; Watson, Christy J.W.; Perez-Paramo, Yadira X; Lazarus, Philip (Drug metabolism and disposition, 2021)
Keywords: Biotransformation; Cannabidiol - metabolism; Cannabinoids - classification; Cannabinoids - metabolism; Cannabinol - metabolism; Cannabis; Cytochrome P-450 Enzyme Inhibitors - pharmacokinetics; Cytochrome P-450 Enzyme System - analysis; Cytochrome P-450 Enzyme System - classification; Dronabinol - analogs & derivatives; Dronabinol - metabolism; Drug Interactions - physiology; Glucuronosyltransferase - metabolism; HEK293 Cells; Hepatobiliary Elimination - drug effects; Humans; FDA; Km; UGT; CBD; AUCRhep; HLM; MS/MS; CBN; THC; AUC; AUCRsys; THC-COOH; 7-OH-CBD; TDI; P450; CBD-COOH; fu, inc; MS; IS; 11-OH-THC; HEK; CB1; HIV; UPLC; LC; THC-COO-Gluc; Ki