Neurotransmitters behind pain relief with transcranial magnetic stimulation - positron emission tomography evidence for release of endogenous opioids

• Published in: European journal of pain Vol. 21; no. 9; p. 1505
• Main Authors: Lamusuo, S, Hirvonen, J, Lindholm, P, Martikainen, I K, Hagelberg, N, Parkkola, R, Taiminen, T, Hietala, J, Helin, S, Virtanen, A, Pertovaara, A, Jääskeläinen, S K
• Format: Journal Article
• Language: English
• Published: England 01.10.2017
• Subjects: Adult; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - metabolism; Cross-Over Studies; Female; Humans; Male; Opioid Peptides - metabolism; Pain - diagnostic imaging; Pain - metabolism; Pain Management; Pain Measurement; Pain Threshold - physiology; Positron-Emission Tomography; Receptors, Dopamine D2 - metabolism; Receptors, Opioid, mu - metabolism; Transcranial Magnetic Stimulation - methods; Young Adult

Repetitive transcranial magnetic stimulation (rTMS) at M1/S1 cortex has been shown to alleviate neuropathic pain. To investigate the possible neurobiological correlates of cortical neurostimulation for the pain relief. We studied the effects of M1/S1 rTMS on nociception, brain dopamine D2 and μ-opio...