Cancer chronotherapy: Principles, applications, and perspectives

• Published in: Cancer Vol. 97; no. 1; pp. 155 - 169
• Main Authors: Mormont, Marie‐Christine, Levi, Francis
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.01.2003; Wiley-Liss
• Subjects: Animals; Antineoplastic agents; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Biological and medical sciences; Chemotherapy; Chronobiology Phenomena; chronopharmacology; Chronotherapy; circadian rhythms; colorectal carcinoma; Colorectal Neoplasms - drug therapy; Drug Tolerance; Humans; Medical sciences; Models, Biological; Pharmacology. Drug treatments; Prognosis; Quality of Life; survival; Antineoplastic agent; Human; Animal model; Rectal disease; Circadian rhythm; Malignant tumor; colorectal carcinoma; circadian rhythms; Survival; Chronopharmacology; Quality of life; Colonic disease; Chemotherapy; Treatment; Animal; Rectum; Digestive diseases; Intestinal disease; chronotherapy; Colon

BACKGROUND Cell physiology is regulated along the 24‐hour timescale by a circadian clock, which is comprised of interconnected molecular loops involving at least nine genes. The cellular clocks are coordinated by the suprachiasmatic nucleus, a hypothalamic pacemaker that also helps the organism adju...