Ergosterol purified from medicinal mushroom Amauroderma rude inhibits cancer growth in vitro and in vivo by up-regulating multiple tumor suppressors

• Published in: Oncotarget Vol. 6; no. 19; pp. 17832 - 17846
• Main Authors: Li, Xiangmin, Wu, Qingping, Xie, Yizhen, Ding, Yinrun, Du, William W., Sdiri, Mouna, Yang, Burton B.
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 10.07.2015
• Subjects: Agaricales - chemistry; Animals; Antineoplastic Agents - pharmacology; Blotting, Western; Cell Death - drug effects; Cell Line, Tumor; Cell Movement - drug effects; Cell Survival - drug effects; Ergosterol - pharmacology; Flow Cytometry; Genes, Tumor Suppressor - drug effects; Humans; Mice; Neoplasms, Experimental - drug therapy; Phytotherapy - methods; Plant Extracts - pharmacology; Real-Time Polymerase Chain Reaction; Research Paper; Up-Regulation

We have previously screened thirteen medicinal mushrooms for their potential anti-cancer activities in eleven different cell lines and found that the extract of Amauroderma rude exerted the highest capacity in inducing cancer cell death. The current study aimed to purify molecules mediating the anti...